10523-64-5Relevant academic research and scientific papers
Pyrazolotriazines as inhibitors of nucleases
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Paragraph 0122; 0123; 0124; 0125; 0126; 0127; 0176-0179, (2016/01/12)
The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
A Convenient and Practical Synthesis of Aminopyrazoles
Mitchell, David,Luo, Yumei,Mcnulty, Lu Anne M.,Buser, Jonas Y.,Mcfarland, Adam D.
, p. 235 - 241 (2015/05/05)
A selective methodology for preparing highly substituted aminopyrazoles has been demonstrated. Starting with an acetophenol core, the corresponding substituted isoxazole is prepared in two steps. The isoxazole is transformed into a benzopyran. Alkylation
