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4-Methyl-4(p-tolyl)-2-pentanone, a chemical compound with the molecular formula C13H18O, is a colorless liquid characterized by its fruity odor. It is widely recognized for its diverse applications across various industries due to its unique properties.

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  • 10528-65-1 Structure
  • Basic information

    1. Product Name: 4-METHYL-4(P-TOLYL)-2-PENTANONE
    2. Synonyms: Nsc23498;4-methyl-4-(4-methylphenyl)pentan-2-one
    3. CAS NO:10528-65-1
    4. Molecular Formula: C13H18O
    5. Molecular Weight: 190.2878
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 10528-65-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 269.3°Cat760mmHg
    3. Flash Point: 101.3°C
    4. Appearance: /
    5. Density: 0.939g/cm3
    6. Vapor Pressure: 0.00733mmHg at 25°C
    7. Refractive Index: 1.492
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-METHYL-4(P-TOLYL)-2-PENTANONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-METHYL-4(P-TOLYL)-2-PENTANONE(10528-65-1)
    12. EPA Substance Registry System: 4-METHYL-4(P-TOLYL)-2-PENTANONE(10528-65-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 10528-65-1(Hazardous Substances Data)

10528-65-1 Usage

Uses

Used in Perfumery and Cosmetics Industry:
4-Methyl-4(p-tolyl)-2-pentanone is used as a fragrance ingredient for its distinctive fruity scent, enhancing the aroma profiles of perfumes and cosmetics, thereby providing a pleasant olfactory experience for consumers.
Used in the Food Industry:
As a flavoring agent, 4-Methyl-4(p-tolyl)-2-pentanone contributes to the enhancement of food flavors, adding depth and complexity to the taste profiles of various food products.
Used in Pharmaceutical Manufacturing:
4-Methyl-4(p-tolyl)-2-pentanone is utilized in the production of pharmaceuticals, serving as a key component in the synthesis of certain medicinal compounds, thus playing a crucial role in drug development.
Used as a Solvent in Industrial Processes:
In various industrial applications, 4-Methyl-4(p-tolyl)-2-pentanone functions as a solvent, facilitating the dissolution of other substances in processes such as chemical reactions and material production.
Used as a Chemical Intermediate:
4-Methyl-4(p-tolyl)-2-pentanone also serves as a chemical intermediate in the synthesis of other compounds, enabling the creation of a range of products through chemical transformations.
Safety Note:
Given its flammable nature, 4-Methyl-4(p-tolyl)-2-pentanone requires careful handling and adherence to proper safety precautions to prevent accidents and ensure the well-being of individuals and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 10528-65-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,2 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10528-65:
(7*1)+(6*0)+(5*5)+(4*2)+(3*8)+(2*6)+(1*5)=81
81 % 10 = 1
So 10528-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H18O/c1-10-5-7-12(8-6-10)13(3,4)9-11(2)14/h5-8H,9H2,1-4H3

10528-65-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methyl-4-(4-methylphenyl)pentan-2-one

1.2 Other means of identification

Product number -
Other names 4-Methyl-4-p-tolyl-pentan-2-on

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10528-65-1 SDS

10528-65-1Relevant articles and documents

Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes

Hao, Hong-Yan,Mao, Yang-Jie,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian

supporting information, p. 2396 - 2402 (2020/03/13)

Selective C(sp3)-C(sp2) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp3)-H and C(sp2)-H bonds represents an attractive alternative toward new C(sp3)-C(sp2) bonds. Herein, we establish a selective inter-and intramolecular C(sp3)-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of β-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo-and regioselectivity.

Comparative study of Heck reaction under thermal and microwave conditions

Solabannavar,Desai, Uday V.,Mane

, p. 2235 - 2237 (2007/10/03)

Comparative study of Heck reaction of various substrates under thermal and microwave irradiation reveals advantage of microwave synthesis.

Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)

-

, (2008/06/13)

Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppressi

Nickel Catalysed 1,4-Addition of Aryl Groups to Enones Using Aryldialkylaluminium Compounds

Westermann, Juergen,Imbery, Ute,Nguyen, Anh Thu,Nickisch, Klaus

, p. 293 - 298 (2007/10/03)

The transmetallation of arylmagnesium halides or aryllithium with Me2AlCl results in the formation of aryldimethylaluminium compounds.These arylaluminium compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac)2 as a catalyst. 3-Aryl ketones are obtained in good yields in these catalytic reactions.Starting from the 3-oxo-Δ1,4-steroids this method gives access to 1α-arylsteroids. - Keywords: conjugate addition; enones; steroids

Steric Effects. A Study of a Rationally Designed System

Bott, Garry,Field, Leslie D.,Sternhell, Sever

, p. 5618 - 5626 (2007/10/02)

The principles for the rational design of systems suitable for the study of steric effects are defined.A suitable molecular framework was synthesized and a study of internal rotaition by dynamic NMR spectroscopy (DNMR) 0f 33 derivatives, differing principally in the nature of the molecular fragment (X), showed the following. (i) For 1 (Y = Me; X = halogen) the rotaition barriers (ΔG excit.) increase smoothly and monotonically with the van der Waals radius of X (rx), which permits the estimation of effective rx for fragments of lower symmetry. (ii) The rotational barriers are the sum of additive contributions, designated interference values (IH-X), which can be used to predict the rotational barriers in 2,2'-disubstituted biphenyls. (iii) A simple geometrical parameter, apparent overlap (r*), which is related to the distortion of the framework in the transition state, is proposed and found to have an excellent linear correlation with the barrier to rotation in 2,2'-disubstituted biphenyls. (iv) This correlation can be used for a semiquantitative estimation of rotational barriers in biaryls and other systems.

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