10528-65-1Relevant articles and documents
Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes
Hao, Hong-Yan,Mao, Yang-Jie,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
supporting information, p. 2396 - 2402 (2020/03/13)
Selective C(sp3)-C(sp2) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp3)-H and C(sp2)-H bonds represents an attractive alternative toward new C(sp3)-C(sp2) bonds. Herein, we establish a selective inter-and intramolecular C(sp3)-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of β-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo-and regioselectivity.
Comparative study of Heck reaction under thermal and microwave conditions
Solabannavar,Desai, Uday V.,Mane
, p. 2235 - 2237 (2007/10/03)
Comparative study of Heck reaction of various substrates under thermal and microwave irradiation reveals advantage of microwave synthesis.
Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH)
-
, (2008/06/13)
Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppressi
Nickel Catalysed 1,4-Addition of Aryl Groups to Enones Using Aryldialkylaluminium Compounds
Westermann, Juergen,Imbery, Ute,Nguyen, Anh Thu,Nickisch, Klaus
, p. 293 - 298 (2007/10/03)
The transmetallation of arylmagnesium halides or aryllithium with Me2AlCl results in the formation of aryldimethylaluminium compounds.These arylaluminium compounds are useful reagents for conjugate additions to enones in the presence of Ni(acac)2 as a catalyst. 3-Aryl ketones are obtained in good yields in these catalytic reactions.Starting from the 3-oxo-Δ1,4-steroids this method gives access to 1α-arylsteroids. - Keywords: conjugate addition; enones; steroids
Steric Effects. A Study of a Rationally Designed System
Bott, Garry,Field, Leslie D.,Sternhell, Sever
, p. 5618 - 5626 (2007/10/02)
The principles for the rational design of systems suitable for the study of steric effects are defined.A suitable molecular framework was synthesized and a study of internal rotaition by dynamic NMR spectroscopy (DNMR) 0f 33 derivatives, differing principally in the nature of the molecular fragment (X), showed the following. (i) For 1 (Y = Me; X = halogen) the rotaition barriers (ΔG excit.) increase smoothly and monotonically with the van der Waals radius of X (rx), which permits the estimation of effective rx for fragments of lower symmetry. (ii) The rotational barriers are the sum of additive contributions, designated interference values (IH-X), which can be used to predict the rotational barriers in 2,2'-disubstituted biphenyls. (iii) A simple geometrical parameter, apparent overlap (r*), which is related to the distortion of the framework in the transition state, is proposed and found to have an excellent linear correlation with the barrier to rotation in 2,2'-disubstituted biphenyls. (iv) This correlation can be used for a semiquantitative estimation of rotational barriers in biaryls and other systems.