- Synthesis and aldose reductase inhibitory activity of 2-substituted-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazoli dine]-2',5'-diones
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Optically active and racemic 2-substituted-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazoli dine]-2',5'-diones were synthesized from (+)-, (-)-, and (±)-6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic acid. These compounds were then evalua
- Yamaguchi,Miura,Usui,Unno,Matsumoto,Fukushima,Mizuno,Kondo,Baba,Kurono
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p. 344 - 348
(2007/10/02)
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- Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
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A process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives of the formula STR1 wherein X and Y are hydrogen atom, halogen atom or alkyl group, and R1 is hydrogen atom or alkyl group, intermediates thereof, as well as a process for the preparation of the intermediates.
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- Process for preparing optically active hydantoins
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Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivatives, wherein said derivatives have the formula STR1 wherein one of V and W is hydrogen and the other is a halogenome
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- Hydantoin derivatives for treating complications of diabetes
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Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula STR1 wherein one of V and W is hydrogen and the other is a halogenomet
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- Antidiabetic spiro-3-heteroazolidines
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A spiro-3-heteroazolidine compound and agents comprising that compound which have special utility as an antidiabetic composition and as a substance to inhibit aldose reductase enzyme activity.
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