105300-40-1

Usage

Uses

Intermediate in the preparation of hydroxylated Nebivolol metabolites.

InChI:InChI=1/C10H7FO4/c11-5-1-2-8-6(3-5)7(12)4-9(15-8)10(13)14/h1-3,9H,4H2,(H,13,14)

Upstream product

• 118803-65-9 (E)-4-(5-fluoro-2-hydroxyphenyl)-4-oxo-2-butenoic acid 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 99199-59-4 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid 
• 123-91-1 1,4-dioxane 
• 105300-39-8 6-fluoro-4-oxochromane-2-carbonitrile 

Downstream Products

• 136087-85-9 (2R,4R)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxamide 
• 136087-85-9 (2S,4R)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxamide 
• 136087-85-9 (2R,4S)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxamide 
• 136087-85-9 fidarestat 
• 136087-85-9 cis-(+/-)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxamide 
• 136087-85-9 trans-(+/-)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxamide 
• 118803-67-1 (2S)-6-fluoro-3,4-dihydro-4-oxo-N-((S)-1-phenylethyl)-2H-1-benzopyran-2-carboxamide 
• 118803-68-2 (2R)-6-fluoro-3,4-dihydro-4-oxo-N-((S)-1-phenylethyl)-2H-1-benzopyran-2-carboxamide 

Relevant academic research and scientific papers

Synthesis and aldose reductase inhibitory activity of 2-substituted-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazoli dine]-2',5'-diones

Optically active and racemic 2-substituted-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazoli dine]-2',5'-diones were synthesized from (+)-, (-)-, and (±)-6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carboxylic acid. These compounds were then evalua

Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof

A process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives of the formula STR1 wherein X and Y are hydrogen atom, halogen atom or alkyl group, and R1 is hydrogen atom or alkyl group, intermediates thereof, as well as a process for the preparation of the intermediates.

Process for preparing optically active hydantoins

Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivatives, wherein said derivatives have the formula STR1 wherein one of V and W is hydrogen and the other is a halogenome

Hydantoin derivatives for treating complications of diabetes

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Antidiabetic spiro-3-heteroazolidines

A spiro-3-heteroazolidine compound and agents comprising that compound which have special utility as an antidiabetic composition and as a substance to inhibit aldose reductase enzyme activity.