Xi:Irritant;10549-76-5Relevant articles and documents
Kinetics and Thermodynamics of Ion Pair Dissociation to Yield Free Solvated Ions. Effect of Steric Hindrance
Kokosinski, Jeanette D.,Forch, Brad E.,Stevenson, Gerald R.,Echegoyen, Luis,Castillo, Carlos A.
, p. 793 - 798 (1980)
The kinetics and thermodynamics of ion pair dissociation involving the anion radicals of ninhydrin, nitrobenzene, and trialkyl-substituted nitrobenzenes ion associated with Na+, K+, Cs+, or (Bu)4N+ in hexamethylphosphoramide (HMPA) were studied via ESR spectroscopy.The large alkyl groups on the (Bu)4N+ cation were found to sterically inhibit the close approach of the positive nitrogen to the anion radical.However, this loose ion pair dissociates less exothermically and exoenergetically than tighter ion pairs involving the other cations due to the poorer solvation of this large cation by the HMPA.The alkyl groups in the ortho positions of the nitrobenzene anion radical also prevent close approach of a solvated cation to yield intimate ion pairs.These loose ion pairs have lower free energies of activation for ion pair disociation.The observed rates and thermodynamics of ion pair dissociation and formation are explained in terms of ion solvation and steric inhibition to ion association.
NOVEL STING AGONISTS
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Paragraph 0727; 0733; 0735, (2020/05/14)
The present invention provides compounds of Formula I′: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.
C6F5XeY Molecules (Y = F and Cl): New synthetic approaches. first structural proof of the organoxenon halide molecule C 6F5XeF
Bilir, Vural,Frohn, Hermann-Josef
, p. 505 - 512 (2013/09/23)
The arylxenonium salt [C6F5Xe][BF4] reacts with different sources of nucleophiles, Y (naked fluoride, [N(CH 3)4]F, the silanes, (CH3)3SiCl and (C2H5)3SiH, and the cadmiumorganyl, Cd(C 6F5)2), in coordinating solvents (C 2H5CN, CH3CN, CD3CN). While the products C6F5XeF, C6F5XeCl, and (C6F5)2Xe are well defined molecules, in reactions with (C2H5)3SiH only decomposition products presumably derived from 6F5XeH6F5XeC2H56F5XeF are discussed.
