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Product FOB Price Min.Order Supply Ability Supplier
Trimethylchlorosilane Manufacturer/High quality/Best price/In stock
Cas No: 75-77-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Cas No: 75-77-4
No Data 1 Kilogram 1 Metric Ton/Month HANGZHOU YUNUO CHEMICAL CO.,LTD Contact Supplier
Price of trimethylchlorosilane CAS NO.75-77-4
Cas No: 75-77-4
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
UIV Chem Trimethylchlorosilane C3H9ClSi 75-77-4
Cas No: 75-77-4
No Data 1 Gram 100 Metric Ton/Month Yurui(Shanghai)Chemical Co.,Ltd Contact Supplier
High quality chlorotrimethylsilane supplier in China
Cas No: 75-77-4
No Data 1 Kilogram 30000 Metric Ton/Year Simagchem Corporation Contact Supplier
High purity Various Specifications Chlorotrimethylsilane CAS:75-77-4
Cas No: 75-77-4
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Chlorotrimethylsilane,CAS 75-77-4
Cas No: 75-77-4
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 3000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Chlorotrimethylsilane CAS 75-77-4 In stock
Cas No: 75-77-4
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
Amadis Chemical offer CAS#75-77-4;CAT#A838505
Cas No: 75-77-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Cas No: 75-77-4
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier

75-77-4 Usage


Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis.


ChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications.

Health Hazard

Similar to other silanes. Toxicity is rated high for inhalation, ingestion and local irritation. May cause death or permanent injury after a very short exposure to small quantities.

Purification Methods

Likely impurities are other chlorinated methylsilanes and tetrachlorosilane (b 57.6o), some of which can form azeotropes. To avoid the latter, very efficient fractional distillation is required. It has been fractionated through a 12 plate glass helices-packed column with only the heart-cut material being used. It has also been fractionated through a 90cm, 19mm diameter Stedman column (p 11). Purify it by redistilling from CaH2 before use. [Sauer et al. J Am Chem Soc 70, 4254 1948, Sauer & Hadsell J Am Chem Soc 70 4258 1948, Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4007.] FLAMMABLE and CORROSIVE.

Chemical Properties

A clear, colorless, caustic and highly flammable liquid with a pungent odour. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene.

Reactivity Profile

Chlorotrimethylsilane reacts vigorously and exothermically with water to produce hydrogen chloride.

General Description

A colorless fuming liquid with a pungent odor. Boiling point 135°F Flash point -18°F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

Fire Hazard

Violent reaction with water. Toxic and irritating hydrogen chloride and phosgene may be formed in fires. Difficult to extinguish, re-ignition may occur. Flashback along vapor trail may occur. Containers may explode in fire. Vapor may explode if ignited in enclosed area. When heated to decomposition or on contact with acids or acid fumes, chloride fumes are emitted. Reacts with surface moisture, releasing hydrogen chloride, which will corrode common metals and form flammable hydrogen gas. Avoid contact with water; Chlorotrimethylsilane readily hydrolyzes, liberating hydrochloric acid. Hazardous polymerization may not occur.

75-77-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (384410)  Chlorotrimethylsilanesolution  1.0 M in THF 75-77-4 384410-100ML 407.16CNY Detail
Aldrich (385433)  Chlorotrimethylsilanesolution  1.0 M in methylene chloride 75-77-4 385433-800ML 2,117.70CNY Detail
Sigma-Aldrich (92360)  Chlorotrimethylsilane  puriss., ≥99.0% (GC) 75-77-4 92360-500ML 2,894.58CNY Detail
Sigma-Aldrich (92360)  Chlorotrimethylsilane  puriss., ≥99.0% (GC) 75-77-4 92360-100ML 745.29CNY Detail
Sigma-Aldrich (92360)  Chlorotrimethylsilane  puriss., ≥99.0% (GC) 75-77-4 92360-25ML 283.14CNY Detail
Aldrich (92361)  Chlorotrimethylsilane  ≥98.0% (GC) 75-77-4 92361-1L 1,242.54CNY Detail
Aldrich (92361)  Chlorotrimethylsilane  ≥98.0% (GC) 75-77-4 92361-500ML 641.16CNY Detail
Aldrich (92361)  Chlorotrimethylsilane  ≥98.0% (GC) 75-77-4 92361-250ML 475.02CNY Detail
Aldrich (92361)  Chlorotrimethylsilane  ≥98.0% (GC) 75-77-4 92361-100ML 274.95CNY Detail
Aldrich (95541)  Chlorotrimethylsilane  produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC) 75-77-4 95541-500G-F 595.53CNY Detail
Aldrich (386529)  Chlorotrimethylsilane  purified by redistillation, ≥99% 75-77-4 386529-1L 4,676.49CNY Detail
Aldrich (386529)  Chlorotrimethylsilane  purified by redistillation, ≥99% 75-77-4 386529-100ML 772.20CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name chlorotrimethylsilane

1.2 Other means of identification

Product number -
Other names Silane, chlorotrimethyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI,Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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