A novel class of compounds called perenosins, and their use in the treatment and/or prevention of cancer or a neoplastic condition.
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Page/Page column 43-44
(2017/06/21)
Perenosins: A new class of anion transporter with anti-cancer activity
A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.
Van Rossom, Wim,Asby, Daniel J.,Tavassoli, Ali,Gale, Philip A.
p. 2645 - 2650
(2016/03/05)
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