89-62-3

Basic information

• Product Name: 4-Methyl-2-nitroaniline
• Synonyms: 2-nitro-p-toluidin;4-Amino-3-nitrotoluene,CI 37110;4-Methyl-2-nitroamiline;4-methyl-2-nitro-benzenamin;4-methyl-2-nitrobenzenamine;4-methyl-2-nitro-Benzenamine;4-Methyl-6-nitroaniline;ai3-09044
• CAS NO: 89-62-3
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15062
• EINECS: 201-924-9
• Product Categories: Intermediates of Dyes and Pigments;Amines;blocks;NitroCompounds;Aromatics;Intermediates
• Mol File: 89-62-3.mol
• Article Data: 25

Chemical Properties

• Melting Point: 115-116 °C(lit.)
• Boiling Point: 169°C (21 mmHg)
• Flash Point: 157°C
• Appearance: Orange to orange-brown/Fine Crystalline Powder
• Density: 1,164 g/cm3
• Vapor Pressure: 0.000963mmHg at 25°C
• Refractive Index: 1.6276 (estimate)
• Storage Temp.: −20°C
• Solubility: 0.2g/l
• PKA: 0.46±0.10(Predicted)
• Water Solubility: Soluble in water (0.2 g/L at 20°C).
• BRN: 879506
• CAS DataBase Reference: 4-Methyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-2-nitroaniline(89-62-3)
• EPA Substance Registry System: 4-Methyl-2-nitroaniline(89-62-3)

Safety Data

• Hazard Codes: T,N,Xi
• Statements: 23/24/25-33-51/53
• Safety Statements: 28-36/37-45-61
• RIDADR: UN 2660 6.1/PG 3
• WGK Germany: 3
• RTECS: XU8227250
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 89-62-3(Hazardous Substances Data)

Usage

Chemical Properties

orange to orange-brown fine crystalline powder

Uses

4-Methyl-2-nitroaniline is used as a red azo dye.

Definition

ChEBI: A C-nitro compound in which the nitro compound is ortho to the amino group and meta to the methyl group of p-toluidine.

Preparation

4-Methyl-2-nitrobenzenamine in oblate sulfuric acid and saponification.

General Description

Red crystals or bright orange powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Methyl-2-nitroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizers .

Fire Hazard

4-Methyl-2-nitroaniline is combustible.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C7H8N2O2/c1-5-2-3-6(8)7(4-5)9(10)11/h2-4H,8H2,1H3

Synthetic route

4-methyl-2-nitroacetanilide (612-45-3) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With Claisen's base	99.4%
With water; potassium hydroxide In ethanol for 3h; Reflux;	92%
With hydrogenchloride

N-(4-methyl-2-nitrophenyl) benzamide (26242-93-3) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 12h;	97%

p-toluidine (106-49-0) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With Oxone; sodium nitrite In nitromethane at 50℃; chemoselective reaction;	86%
With 3-methyl-1-sulfonic acid imidazolium nitrate In dichloromethane at 20℃; for 0.25h;	81%
With tetrachloromethane; diethyl ether; dinitrogen pentoxide

ethyl p-tolylcarbamate (5255-66-3) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With tert.-butylnitrite; palladium diacetate In 1,4-dioxane at 90℃; Reagent/catalyst;	80%
With tert.-butylnitrite; hydrogen; copper dichloride In 1,4-dioxane at 90℃; for 6h; Reagent/catalyst; Temperature;	79%

5-methylbenzofuroxan (19164-41-1) → 5-methyl-2-nitroaniline (578-46-1) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With iron(II) sulfate In water; dimethyl sulfoxide Ambient temperature; Title compound not separated from byproducts;	A 65% B 35%
With iron(II) sulfate In dimethyl sulfoxide at 20℃; for 1h;	A 60% B 26%
With HbO2(2+) In phosphate buffer; dimethyl sulfoxide for 1h; pH=7.4;	A 38 % Chromat. B 54 % Chromat.

trinitromethane (517-25-9) + 4-methylphenyl isocyanide (7175-47-5) → p-toluidine (106-49-0) + 3-(2-nitro-4-methylphenyl)-1,2,3,4-oxatriazolium-5-olate + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
	A 3% B 48% C 21%

4-methylphenyl isocyanide (7175-47-5) → p-toluidine (106-49-0) + 3-(2-nitro-4-methylphenyl)-1,2,3,4-oxatriazolium-5-olate + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With trinitromethane	A 3% B 48% C 21%

N-acetonyl-4-methyl-2-nitro-N-p-tolylsulphonylaniline (71467-88-4) → 2,7-dimethylquinoxaline (39859-62-6) + di(p-tolyl) disulfide (103-19-5) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In acetic acid 1.) 65 deg C, 1.5 h, 2.) 100 deg C, 1.5 h;	A 42% B n/a C n/a

ethanol (64-17-5) + 1,3-bis-(4-methyl-2-nitro-phenyl)-triazene → 1-methyl-3-nitrobenzene (99-08-1) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
at 170℃; im geschlossenen Rohr;

4-methyl-2-nitrophenol (119-33-5) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With ammonia at 170 - 180℃;
With formic acid; ammonia; water at 150℃;

N-(4-methylphenyl)formamide (3085-54-9) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With sulfuric acid; water; nitric acid und Eintragen des Reaktionsgemisches in Wasser;

N-(4-methylphenyl)benzamide (582-78-5) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With nitric acid Erhitzen des entstandenen Benzoylderivats mit konz.Salzsaeure auf 200grad;
With nitric acid Erhitzen des entstandenen Benzoylderivats mit verd. Natronlauge;
Multi-step reaction with 2 steps 1: nitric acid; copper(II) nitrate hydrate; oxygen / acetonitrile; water / 12 h / 100 °C / 760.05 Torr 2: potassium hydroxide / methanol / 12 h / 20 °C View Scheme

3,4-Dinitrotoluene (610-39-9) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With methanol; ammonia at 150℃; unter Druck;

3,4-Dinitrotoluene (610-39-9) → 5-methyl-2-nitroaniline (578-46-1) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With hydrogenchloride; tin(ll) chloride at 7℃;
With methanol; ammonia at 150℃; unter Druck;

BTB01434 (3968-10-3) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With sulfuric acid
With sulfuric acid

acetic anhydride (108-24-7) + para-methyl anilinium nitrate (32954-54-4) → 4-Methylacetanilide (103-89-9) + 4-methyl-2-nitroaniline (89-62-3) + N-nitro-p-toluidine (20020-14-8)

p-toluidine (106-49-0) → 4-Methyl-3-nitroanilin (119-32-4) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With sulfuric acid; nitric acid wendet man viel Schwefelsaeure an, so entsteht nur 2-Nitro-4-amino-toluol;
With sulfuric acid; nitric acid

2,2,2-trichloro-N,N'-bis(4-methylphenylethane)-1,1-diamine (39809-78-4) + acetic acid (64-19-7) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With nitric acid Eingeiessen des Produktes in Wasser;

1-chloro-4-methyl-2-nitro-benzene (89-60-1) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With ammonia at 175℃; im Autoklaven;

4-Methylacetanilide (103-89-9) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With nitric acid das entstandenene Acetylderivat verseift man durch Erwaermen mit alkoh.Kali;
With nitric acid; acetic acid
With hydrogenchloride; nitric acid das Acetylderivat entsteht;

N-nitro-p-toluidine (20020-14-8) → 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With hydrogenchloride; diethyl ether

1-methyl-3-nitrobenzene (99-08-1) → 2-Methyl-6-nitroaniline (570-24-1) + 2-methyl-4-nitro-benzenamine (99-52-5) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
With potassium tert-butylate; N,N,N-trimethylhydrazinium iodide In dimethyl sulfoxide Ambient temperature; Yield given. Yields of byproduct given;

2-p-tolylisoindoline-1,3-dione (2142-03-2) + nitric acid (7697-37-2) → 4-Methyl-3-nitroanilin (119-32-4) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
und Kochen der entstandenen Nitro-Verbindungen mit 2n-Natronlauge;

hydrogenchloride (7647-01-0) + N-(4-methyl-2-nitrophenyl) benzamide (26242-93-3) → benzoic acid (65-85-0) + 4-methyl-2-nitroaniline (89-62-3)

Conditions	Yield
at 200℃;

N-(4-methyl-2-nitrophenyl) benzamide (26242-93-3) + alkali → benzoic acid (65-85-0) + 4-methyl-2-nitroaniline (89-62-3)

sulfuric acid (7664-93-9) + nitric acid (7697-37-2) + p-toluidine (106-49-0) → 4-Methyl-3-nitroanilin (119-32-4) + 4-methyl-2-nitroaniline (89-62-3)

tetrachloromethane (56-23-5) + diethyl ether (60-29-7) + p-toluidine (106-49-0) + N2O5 → toluene-4-diazonium ; nitrate + 4-methyl-2-nitroaniline (89-62-3) + N-nitro-p-toluidine (20020-14-8) + nitrate p-toluidine

hydrogenchloride (7647-01-0) + diethyl ether (60-29-7) + N-nitro-p-toluidine (20020-14-8) → 4-methyl-2-nitroaniline (89-62-3)

4-fluoro-3-nitrotoluene (446-11-7) + ammonia (7664-41-7) → 4-methyl-2-nitroaniline (89-62-3)

4-methyl-2-nitroaniline (89-62-3) → 2-amino-5-methyl-3-nitrophenyliodide (123158-77-0)

Conditions	Yield
With silver(II) sulfate; iodine In ethanol at 20℃; for 36h; Darkness;	100%
With iodine; silver sulfate In ethanol at 20℃; for 36h; Darkness;	100%
With silver(II) sulfate; iodine for 18h;	100%

dimethyl sulfate (77-78-1) + 4-methyl-2-nitroaniline (89-62-3) → 4,N-dimethyl-2-nitroaniline (4600-08-2)

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 20℃; Methylation;	99%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 20℃;	98%

N-phenylacetoacetamide (102-01-2) + 4-methyl-2-nitroaniline (89-62-3) → pigment yellow 1 (2512-29-0)

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Time;	99%
With hydrogenchloride; sodium nitrite In water at 20℃; for 0.666667h; Green chemistry;	99%
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; C25H20N6O6S2; sodium nitrite In water at 10℃; for 1h; Stage #2: N-phenylacetoacetamide With sodium acetate; acetic acid In water at 25 - 90℃; for 2.5h; pH=6;
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 10℃; for 1h; Stage #2: N-phenylacetoacetamide With sodium hydroxide; sodium acetate; acetic acid In water at 25 - 90℃; for 2.5h; pH=6;
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride In water at 75 - 80℃; for 1h; Stage #2: With sodium nitrite In water at 0 - 5℃; for 0.75h; Stage #3: N-phenylacetoacetamide Further stages;

edaravone (89-25-8) + 4-methyl-2-nitroaniline (89-62-3) → pigment orange 6

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: 3-methyl-1-phenylpyrazolin-5-(4H)-one In water at 20℃; for 0.166667h;	99%

2'-methoxyacetoacetanilide (92-15-9) + 4-methyl-2-nitroaniline (89-62-3) → pigment yellow 203

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: 2'-methoxyacetoacetanilide In water at 20℃; for 1h;	99%

β-naphthol (135-19-3) + 4-methyl-2-nitroaniline (89-62-3) → ((4-methyl-2-nitrophenyl)azo)-2-naphthol (2425-85-6)

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Stage #2: β-naphthol In water at 60℃; for 1h; Temperature;	99%
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Green chemistry; Stage #2: β-naphthol In water at 60℃; for 1h; Green chemistry;	99%

3-methyl-1-phenylpyrazolin-5(4H)-one (19735-89-8) + 4-methyl-2-nitroaniline (89-62-3) → pigment orange 6

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 20℃; for 0.333333h; Green chemistry; Stage #2: 3-methyl-1-phenylpyrazolin-5(4H)-one In water at 20℃; for 0.166667h; Green chemistry;	99%

methanol (67-56-1) + 4-methyl-2-nitroaniline (89-62-3) → 5-methylbenzimidazole (614-97-1)

Conditions	Yield
With palladium with copper supported on alumina In water at 179.84℃; under 26252.6 Torr; for 12h; Autoclave;	98.7%

4-methyl-2-nitroaniline (89-62-3) → 2-bromo-4-methyl-6-nitroaniline (827-24-7)

Conditions	Yield
With bromine; acetic acid for 0.5h;	98%
Stage #1: 4-methyl-2-nitroaniline In acetic acid at 50℃; Stage #2: With bromine for 0.5h;	98%
With bromine; acetic acid at 20℃; for 1h;	98%

4-(5-chloro-2-methoxybenzamido-N-methylene)benzene sulfonyl chloride + 4-methyl-2-nitroaniline (89-62-3) → 5-chloro-2-methoxy-N-[(N-2-nitro-4-methylphenyl-4-sulfamoyl)benzyl]benzamide

Conditions	Yield
With sodium carbonate In dichloromethane; water at 20℃; for 24h;	98%

1-allyloxy-2-iodobenzene (24892-63-5) + 4-methyl-2-nitroaniline (89-62-3) → C16H16N2O3

Conditions	Yield
With potassium phosphate; silver hexafluoroantimonate; chloro[di(1-adamantyl)-2-dimethylaminophenylphosphine]gold(I) In 1,2-dichloro-ethane at 80℃; chemoselective reaction;	98%

ethanol (64-17-5) + 4-methyl-2-nitroaniline (89-62-3) → 2,5-dimethylbenzimidazole (1792-41-2)

Conditions	Yield
With palladium with copper supported on alumina In water at 179.84℃; under 26252.6 Torr; for 12h; Autoclave;	97.5%
With TiO2-P25 nanoparticles In acetonitrile for 3h; UV-irradiation;

propan-1-ol (71-23-8) + 4-methyl-2-nitroaniline (89-62-3) → 2-ethyl-5-methyl-1H-benzo[d]imidazole (30411-81-5)

Conditions	Yield
With palladium with copper supported on alumina In water at 179.84℃; under 26252.6 Torr; for 12h; Autoclave;	97.5%

4-methyl-2-nitroaniline (89-62-3) → 4-methyl-1,2-diaminobenzene (496-72-0)

Conditions	Yield
With hydrogen; nickel In methanol at 65 - 75℃; for 1h; Autoclave; Inert atmosphere;	97%
With aluminum oxide; hydrazine hydrate; iron(III) chloride at 111℃; for 0.1h; Irradiation; microwave;	96%
With hydrazine hydrate In ethanol at 70℃; for 4h; chemoselective reaction;	94%

4-methyl-2-nitroaniline (89-62-3) → 2,3-dibromo-5-methylnitrobenzene (73557-63-8)

Conditions	Yield
With tert.-butylnitrite; bromine; copper(ll) bromide In acetonitrile at 50℃; for 0.5h;	97%
Multi-step reaction with 2 steps 1: water; bromine View Scheme

2-chloro-4,6-dimethylquinoline (3913-18-6) + 4-methyl-2-nitroaniline (89-62-3) → 4,6-dimethyl-2-(4-methyl-2-nitroanilino)quinoline (158470-92-9)

Conditions	Yield
at 150 - 160℃; for 10h;	97%

acrylic acid methyl ester (292638-85-8) + 4-methyl-2-nitroaniline (89-62-3) → methyl (E)-3-(4′-methyl-2′-nitrophenyl)acrylate (99843-45-5)

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With tert.-butylnitrite In methanol at 0℃; for 0.5h; Stage #2: acrylic acid methyl ester With methanesulfonic acid; palladium diacetate In methanol at 0 - 25℃; Heck-Matsuda reaction;	97%
With palladium diacetate; toluene-4-sulfonic acid In methanol at 60℃; for 1.5h; Inert atmosphere;	77%
Stage #1: 4-methyl-2-nitroaniline With methanesulfonic acid In methanol at 25℃; Stage #2: With tert.-butylnitrite In methanol at 25℃; for 0.00833333h; Stage #3: acrylic acid methyl ester With palladium diacetate In tetrahydrofuran; methanol at 25 - 40℃; for 0.278333h; Reagent/catalyst; Time;	75%
With tert.-butylnitrite In methanol at 25℃; for 24h; chemoselective reaction;	71%

3-chloro-2,4-dimethoxypyridine + 4-methyl-2-nitroaniline (89-62-3) → C14H15N3O4

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); C35H38NO4P In 1,4-dioxane at 100℃; for 18h;	97%

chloroacetyl chloride (79-04-9) + 4-methyl-2-nitroaniline (89-62-3) → 2-chloro-N-(4-methyl-2-nitrophenyl)acetamide (72196-97-5)

Conditions	Yield
In N,N-dimethyl-formamide Cooling with ice;	96%
With benzene
With triethylamine In dichloromethane at 20℃; for 24h;

benzyl bromide (100-39-0) + 4-methyl-2-nitroaniline (89-62-3) → 4-methyl-2-nitro-N-benzylaniline (22019-66-5)

Conditions	Yield
In water at 100℃; for 1.5h;	96%
With pyridine In dichloromethane for 16h; Reflux;	90.3%
With potassium carbonate In N,N-dimethyl-formamide at 110 - 120℃; for 4h;
In water at 110℃; Sealed tube;

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) + 4-methyl-2-nitroaniline (89-62-3) → 6-methyl-2,3-di-p-tolylquinoxaline (16107-87-2)

Conditions	Yield
With tin(ll) chloride In ethanol; water for 0.333333h; Reflux;	96%

2-hydroxy-6,6-dimethyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester (300680-16-4) + 4-methyl-2-nitroaniline (89-62-3) → C18H21N3O6

Conditions	Yield
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: 2-hydroxy-6,6-dimethyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester With sodium hydroxide In water for 3h; pH=7.5 - 9;	95.4%
Stage #1: 4-methyl-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: 2-hydroxy-6,6-dimethyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester With sodium hydroxide In water for 3h; pH=7.5 - 9; Alkaline aqueous solution;	95.4%

orthoformic acid triethyl ester (122-51-0) + 4-methyl-2-nitroaniline (89-62-3) → 5-methylbenzimidazole (614-97-1)

Conditions	Yield
With 10% Pd/C; hydrogen; acetic acid In methanol at 20℃; under 760.051 Torr; for 8h;	95%

carbon dioxide (124-38-9) + 4-methyl-2-nitroaniline (89-62-3) → 5-methylbenzimidazole (614-97-1)

Conditions	Yield
With palladium 10% on activated carbon; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In acetonitrile at 70℃; under 7500.75 Torr; for 15h;	95%
With dimethylamine borane; potassium carbonate In ethanol; water under 15001.5 Torr; for 18h; Catalytic behavior; Autoclave;	87%

benzaldehyde (100-52-7) + 4-methyl-2-nitroaniline (89-62-3) → 5-methyl-2-phenyl-1H-1,3-benzimidazole (2963-65-7)

Conditions	Yield
With hydrogen In ethyl acetate at 60℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	95%

benzaldehyde (100-52-7) + 4-methyl-2-nitroaniline (89-62-3) → 4-methyl-2-nitro-N-benzylaniline (22019-66-5)

Conditions	Yield
Stage #1: benzaldehyde; 4-methyl-2-nitroaniline With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In water; ethyl acetate	94%

Triethyl orthoacetate (78-39-7) + 4-methyl-2-nitroaniline (89-62-3) → 2,5-dimethylbenzimidazole (1792-41-2)

Conditions	Yield
With 10% Pd/C; hydrogen; acetic acid In methanol at 20℃; under 760.051 Torr;	94%

4-methyl-2-nitroaniline (89-62-3) + 2.3-butanediol (513-85-9) → 2,3,6-trimethylquinoxaline (17635-21-1)

Conditions	Yield
With sodium hydroxide In toluene at 120℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry;	94%

Upstream product

• 119-33-5 4-methyl-2-nitrophenol 
• 612-45-3 4-methyl-2-nitroacetanilide 
• 610-39-9 3,4-Dinitrotoluene 
• 108-24-7 acetic anhydride 
• 32954-54-4 para-methyl anilinium nitrate 
• 39809-78-4 2,2,2-trichloro-N,N'-bis(4-methylphenylethane)-1,1-diamine 
• 64-19-7 acetic acid 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 103-89-9 4-Methylacetanilide 
• 20020-14-8 N-nitro-p-toluidine 
• 517-25-9 trinitromethane 
• 7175-47-5 4-methylphenyl isocyanide 
• 19164-41-1 5-methylbenzofuroxan 
• 2142-03-2 2-p-tolylisoindoline-1,3-dione 

Downstream Products

• 33238-34-5 N-(4'-methyl-o-nitrophenyl)phthalimide 
• 109471-75-2 2-(4-methyl-2-nitro-phenyl)-benz[de]isoquinoline-1,3-dione 
• 100663-77-2 (4-methyl-2-nitro-phenyl)-carbamic acid ethyl ester 
• 52426-98-9 N,N'-bis-(4-methyl-2-nitro-phenyl)-oxalamide 
• 612-45-3 4-methyl-2-nitroacetanilide 
• 871879-52-6 2-(4-methyl-2-nitro-anilino)-benzaldehyde 
• 22019-66-5 4-methyl-2-nitro-N-benzylaniline 
• 26242-93-3 N-(4-methyl-2-nitrophenyl) benzamide 
• 37637-58-4 ethyl-(4-methyl-2-nitrophenyl)amine 
• 62573-36-8 N-(4-methyl-2-nitro-phenyl)-glycine 
• 108012-59-5 (4-methyl-2-nitro-phenyl)-carbamic acid benzyl ester 
• 99056-11-8 N-(4-methyl-2-nitro-phenyl)-β-alanine nitrile 
• 72196-97-5 N-(4-methyl-2-nitrophenyl)-2-chloroacetamide 
• 71468-13-8 2-[(4-methyl-2-nitrophenyl)amino]-1-phenylethanone 

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The invention relates to an aromatic ring liquid crystal compound, a liquid crystal composition and an assembly suitable for a microwave region and a millimeter wave region of a high-frequency technology or an electromagnetic spectrum, and particularly a phase shifter and a microwave array antenna. The liquid crystal composition provided by the invention at least comprises a compound represented by a general formula I. The liquid crystal composition provided by the invention is good in stability, high in response speed and wide in liquid crystal phase temperature range.

4-methyl-2-nitroaniline synthesis method

The invention discloses a 4-methyl-2-nitroaniline synthesis method, which comprises: carrying out amino protection with ethyl chloroformate by using 4-methylaniline as a raw material to generate N-(p-toluene)ethyl carbamate; adding an oxidant and a copper salt catalyst, and carrying out a reaction for a certain time at a temperature of 50-120 DEG C in a reaction solvent by using a nitroso-containing compound as a nitrating agent to prepare a corresponding protected o-nitro-p-toluidine; and carrying out hydrolysis to obtain the target product. According to the present invention, the method hasadvantages of simple preparation process, mild reaction condition, high yield and environment protection.

Perenosins: A new class of anion transporter with anti-cancer activity

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.