1055361-96-0

Basic information

• Product Name: bisMPA dendron
• Synonyms: Polyester bis-MPA dendron, 4 hydroxyl, 1 acetylene
• CAS NO: 1055361-96-0
• Molecular Formula: C₁₈H₂₈O₁₀
• Molecular Weight: 404.41
• Mol File: 1055361-96-0.mol

Chemical Properties

• Melting Point: 101-105°C
• Boiling Point: 569.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.12±0.10(Predicted)
• CAS DataBase Reference: bisMPA dendron(CAS DataBase Reference)
• NIST Chemistry Reference: bisMPA dendron(1055361-96-0)
• EPA Substance Registry System: bisMPA dendron(1055361-96-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1055361-96-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
BisMPA dendron is used as a synthetic building block for the creation of complex molecular structures. Its multiple branches allow for the attachment of various functional groups, making it a valuable tool in the synthesis of advanced materials and compounds.
Used in Drug Delivery Systems:
In the pharmaceutical industry, bisMPA dendron is used as a component in drug delivery systems. Its ability to couple with various functional molecules, such as carbohydrates, fluorescent dyes, and polymers, enables the development of targeted drug delivery systems with enhanced bioavailability and therapeutic efficacy.
Used in Diagnostics and Imaging:
BisMPA dendron is used as a component in diagnostic and imaging applications. Its compatibility with fluorescent dyes and other imaging agents allows for the development of highly sensitive and specific detection systems for various medical conditions.
Used in Material Science:
In the field of material science, bisMPA dendron is used as a building block for the development of advanced materials with unique properties. Its ability to form complex structures and couple with various functional molecules makes it a promising candidate for the creation of novel materials with tailored properties for specific applications.
Used in Nanotechnology:
BisMPA dendron is used as a component in the development of nanoscale devices and systems. Its ability to form multiple branches and couple with various functional molecules makes it a valuable tool for the creation of nanoscale structures with specific properties and functions.

Upstream product

• 16837-14-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid 
• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 408322-03-2 2,2,5-trimethyl-1,3-dioxane-5-carboxylic anhydride 
• 205878-78-0 isopropylidene-[G-2]-COOH 
• 919988-17-3 2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) 
• 919988-15-1 propargyl 2,2,5-trimethyl-1,3-dioxane-5-carboxylate 
• 873849-85-5 prop-2-yn-1-yl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate 

Downstream Products

• 1351959-64-2 C₄₆H₄₀N₄O₂₆ 

Relevant articles and documents

Convergent synthesis of glycodendropeptides by click chemistry approaches

Mannosylation facilitates the uptake of immunogenic peptides by antigen-processing cells expressing mannose receptors at their surface. Mannose-receptor interactions not only induce internalization but also trigger strong T-cell stimulation, such as that of the dendritic cell-specific intercellular ICAM-3 grabbing non-integrin (DC-SIGN), a lectin that plays a key role in the immune response against different pathogens. We describe here two efficient synthetic strategies for structurally well-defined mannose-displaying glycodendropeptides with up to 16 peptide and 9 mannose copies. Our approaches integrate previously optimized synthetic methods for producing both peptide and glycan dendrimers, and make extensive use of CuI-catalyzed Huisgen 1,3-dipolar cycloaddition for both the building of the glycodendron moieties and their subsequent conjugation to the peptide components. These strategies are versatile and straightforward enabling full control of chemical structure as well as readily tunable valency. Mannose-displaying glycodendropeptides with up to 16 peptide and 9 mannose copies have been synthesized making extensive use of CuI-catalyzed Huisgen 1,3-dipolar cycloaddition for both the building of the glycodendrons and their subsequent conjugation to single peptides or peptide dendrimers based on a branched lysine scaffold. Copyright

Dendron-Mediated Engineering of Interparticle Separation and Self-Assembly in Dendronized Gold Nanoparticles Superlattices

Self-assembly of nanoparticles into designed structures with controlled interparticle separations is of crucial importance for the engineering of new materials with tunable functions and for the subsequent bottom-up fabrication of functional devices. In t

Self-Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass pr

Self-assembling amphiphilic Janus dendrimers: Mesomorphic properties and aggregation in water

The self-assembly behaviour both in bulk and in water of amphiphilic dendrimeric derivatives based on bis-MPA is the central theme of this article. The designed molecules possess two parts with different polarity; this feature is the key factor that forces their self-assembly in water into supramolecular architectures, due to hydrophobic interactions between the lipophilic fractions of the molecules, and the appearance of mesomorphic order in bulk in response to a variation of temperature (thermotropic liquid crystals). The effects provoked by the hydrophilic/lipophilic balance of the molecule were studied varying the generation of the corresponding dendrons and combining them via CuAAC click chemistry in order to obtain symmetrical and unsymmetrical final Janus dendrimers. The ability of the aggregates formed in water to encapsulate hydrophobic drugs has also been explored.

Multivalent, bifunctional dendrimers prepared by click chemistry

Unsymmetrical dendrimers, containing both mannose binding units and coumarin fluorescent units, have been prepared using click chemistry and shown to be highly efficient, dual-purpose recognition/detection agents for the inhibition of hemagglutination. The Royal Society of Chemistry 2005.

HYBRID NANOPARTICLES CONTAINING DENDRONS, METHODS OF PRODUCING SUCH HYBRID NANOPARTICLES, AND USES THEREOF

The present disclosure relates to a hybrid nanoparticle comprising a metallic core and at least one lipophilic dendron attached to the surface of the metallic core, and methods of producing such hybrid nanoparticles. The present disclosure also relates to

Degradable self-assembling dendrons for gene delivery: Experimental and theoretical insights into the barriers to cellular uptake

This paper uses a combined experimental and theoretical approach to gain unique insight into gene delivery. We report the synthesis and investigation of a new family of second-generation dendrons with four triamine surface ligands capable of binding to DN