bisMPA dendron

Base Information

• Chemical Name: bisMPA dendron
• CAS No.: 1055361-96-0
• Molecular Formula: C₁₈H₂₈O₁₀
• Molecular Weight: 404.414
• Mol file: 1055361-96-0.mol

Synonyms:2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(3-hydroxy-2-(hydroxylmethyl)-2-methylpropanoate)

Chemical Property of bisMPA dendron

Chemical Property:

• Melting Point: 101-105°C
• Boiling Point: 569.3±45.0 °C(Predicted)
• PKA: 13.12±0.10(Predicted)
• Density: 1.304±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Polyester bis-MPA dendron, 4 hydroxyl, 1 acetylene hydroxyl surface groups ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Acetylene dendrons can be coupled to azide functional molecules such as carbohydrates, fluorescent dyes and polymers.

Technology Process of bisMPA dendron

There total 8 articles about bisMPA dendron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) (919988-17-3) → 2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(3-hydroxy-2-(hydroxylmethyl)-2-methylpropanoate) (1055361-96-0)

Guidance literature:

With DOWEX resin; In methanol; at 40 ℃; for 2h;

DOI:10.1021/jacs.5b06306

Reference yield: 94.0%

2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate) (919988-17-3) → 2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(3-hydroxy-2-(hydroxylmethyl)-2-methylpropanoate) (1055361-96-0)

Guidance literature:

In methanol; at 40 ℃;

DOI:10.1002/ejoc.201200428

Reference yield:

prop-2-yn-1-yl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate (873849-85-5) → 2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(3-hydroxy-2-(hydroxylmethyl)-2-methylpropanoate) (1055361-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / DMAP; pyridine / CH₂Cl₂ / 20 °C

2: Dowex 50W-X₂-200 / methanol / 40 °C

With pyridine; dmap; Dowex 50W-X₂-200; In methanol; dichloromethane;

DOI:10.1039/b512021g

upstream raw materials:

2-methyl-2-((prop-2-yn-1-yloxy)carbonyl)propane-1,3-diyl bis(2,2,5-trimethyl-1,3-dioxane-5-carboxylate)

prop-2-yn-1-yl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

propargyl 2,2,5-trimethyl-1,3-dioxane-5-carboxylate

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid

Downstream raw materials:

C₄₆H₄₀N₄O₂₆

Refernces

• 1、 Jishkariani, Davit,Diroll, Benjamin T.,Cargnello, Matteo,Klein, Dahlia R.,Hough, Lawrence A.,Murray, Christopher B.,Donnio, Bertrand. "Dendron-Mediated Engineering of Interparticle Separation and Self-Assembly in Dendronized Gold Nanoparticles Superlattices". . p. 10728 - 10734. Retrieved 2015.
• 2、 Fedeli, Elisabetta,Lancelot, Alexandre,Serrano, José Luis,Calvo, Pilar,Sierra, Teresa. "Self-assembling amphiphilic Janus dendrimers: Mesomorphic properties and aggregation in water". . p. 1960 - 1967. Retrieved 2015.
• 3、 -. "HYBRID NANOPARTICLES CONTAINING DENDRONS, METHODS OF PRODUCING SUCH HYBRID NANOPARTICLES, AND USES THEREOF". Page/Page column 33. . Retrieved 2017/01/31.