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1056427-10-1

2-Methyl-2-(2-nitrophenyl)propanoyl chloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1056427-10-1 Structure

  • Basic information

    1. Product Name: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride
    2. Synonyms: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride
    3. CAS NO:1056427-10-1
    4. Molecular Formula: C10H10ClNO3
    5. Molecular Weight: 227.6443
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1056427-10-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(1056427-10-1)
    11. EPA Substance Registry System: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(1056427-10-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1056427-10-1(Hazardous Substances Data)

1056427-10-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1056427-10-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,4,2 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1056427-10:
(9*1)+(8*0)+(7*5)+(6*6)+(5*4)+(4*2)+(3*7)+(2*1)+(1*0)=131
131 % 10 = 1
So 1056427-10-1 is a valid CAS Registry Number.

1056427-10-1Relevant articles and documents

The 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Group: A Novel Protecting Group in Carbohydrate Chemistry

Liu, Hui,Zhou, Si-Yu,Wen, Guo-En,Liu, Xu-Xue,Liu, De-Yong,Zhang, Qing-Ju,Schmidt, Richard R.,Sun, Jian-Song

supporting information, p. 8049 - 8052 (2019/10/11)

The 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) group was introduced to synthetic carbohydrate chemistry as a protecting group (PG) for the first time. Benefiting from a unique chemical structure and novel deprotection conditions, the DMNPA group can be cleaved rapidly and mutually orthogonal to other PGs. Orchestrated application of the DMNPA group with other PGs led to the highly efficient synthesis of the glycan of thornasterside A.

Peptide conjugates of 4-aminocyclophosphamide as prodrugs of phosphoramide mustard for selective activation by prostate-specific antigen (PSA)

Jiang, Yongying,Hu, Longqin

, p. 7507 - 7514 (2013/11/19)

In our continued effort to develop prodrugs of phosphoramide mustard, conjugates of 4-aminocyclophosphamide (4-NH2-CPA) with three PSA-specific peptides were synthesized and evaluated as substrates of PSA. These include conjugates of cis-(2R,4R)-4-NH2-CPA with a tetrapeptide Succinyl-Ser-Lys-Leu-Gln-OH, a hexapeptide Succinyl-His-Ser-Ser-Lys-Leu-Gln-OH, and a pentapeptide Glutaryl-Hyp-Ala-Ser-Chg-Gln-OH. These conjugates were cleaved by PSA efficiently and exclusively after the expected glutamine residue to release 4-NH2-CPA, the activated prodrug form of phosphoramide mustard. The cleavage was most efficient for the pentapeptide conjugate 3 (Glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-CPA), which showed a half-life of 55 min with PSA, followed by the hexapeptide conjugate 2 (Succinyl-His-Ser-Ser-Lys-Leu-Gln- NH-CPA) and the tertrapeptide conjugate 1 (Succinyl-Ser-Lys-Leu-Gln-NH-CPA) with half-lives of 6.5 and 12 h, respectively. These results indicate a potential of the conjugate 3 as an anticancer prodrug of phosphoramide mustard for selective PSA activation.

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard

Jiang, Yongying,Hu, Longqin

body text, p. 4059 - 4063 (2009/04/06)

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide isomers (DMNA-NH-CPA, 4) were synthesized stereospecifically from Boc-l-Hse(OBn)-OH and the degradation of the corresponding reduced amine 5a was investigated by UV/vis spectroscopy and LC/M

Relationships between Structure and Kinetics of Cyclization of 2-Aminoaryl Amides: Potential Prodrugs of Cyclization-Activated Aromatic Mustards

Atwell, Graham J.,Sykes, Bridget M.,O'Connor, Charmian J.,Denny, William A.

, p. 371 - 380 (2007/10/02)

2-Nitroaryl amides of general structure I are proposed as bioreducible prodrugs, capable of releasing cytotoxic aminoaniline mustards V on bioactivation by spontaneous cyclization of the resulting 2-aminoaryl amides II via a tetrahedral intermediate, III.

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