2-Methyl-2-(2-nitrophenyl)propanoyl chloride

Base Information

• Chemical Name: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride
• CAS No.: 1056427-10-1
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.647
• Mol file: 1056427-10-1.mol

Synonyms:2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride

Chemical Property of 2-Methyl-2-(2-nitrophenyl)propanoyl chloride

Chemical Property:

Purity/Quality:

2-Methyl-2-(2-nitrophenyl)propanoylchloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-2-(2-nitrophenyl)propanoyl chloride

There total 2 articles about 2-Methyl-2-(2-nitrophenyl)propanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-(2-nitrophenyl)propanoic acid (126802-52-6) → 2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride (1056427-10-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; for 0.25h; Heating;

DOI:10.1021/jm00029a009

Reference yield:

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester (136764-87-9) → 2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride (1056427-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / conc. H₂SO₄, H₂O / 0 °C

2: SOCl₂, DMF / 0.25 h / Heating

With thionyl chloride; sulfuric acid; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00029a009

Reference yield: 75.0%

C12H16N2O4 + 2,2-dimethyl-2-(2-nitrophenyl)acetyl chloride (1056427-10-1) → Nα-DMNA-D-Hse(Cbz)-NH2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2013.09.039

upstream raw materials:

2-methyl-2-(2-nitrophenyl)propanoic acid

2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester

Downstream raw materials:

N-(3-quinolyl)-2-methyl-2-(2-nitrophenyl)propanamide

N-<4-(methylsulfonyl)phenyl>-2-methyl-2-(2-nitrophenyl)propanamide

N-(4-methoxyphenyl)-2-methyl-2-(2-nitrophenyl)propanamide

N-(2-phenylethyl)-2-methyl-2-(2-nitrophenyl)propanamide