1057393-44-8

Basic information

• Product Name: (4-Iodo-pyridin-2-yl)-hydrazine
• Synonyms: (4-Iodo-pyridin-2-yl)-hydrazine;2-Hydrazinyl-4-iodopyridine
• CAS NO: 1057393-44-8
• Molecular Formula: C₅H₆IN₃
• Molecular Weight: 235.02571
• Mol File: 1057393-44-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Iodo-pyridin-2-yl)-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Iodo-pyridin-2-yl)-hydrazine(1057393-44-8)
• EPA Substance Registry System: (4-Iodo-pyridin-2-yl)-hydrazine(1057393-44-8)

Safety Data

• Hazardous Substances Data: 1057393-44-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-Iodo-pyridin-2-yl)-hydrazine is used as a building block for the synthesis of various pharmaceuticals due to its versatile reactivity and ability to participate in a wide range of organic transformations and reactions. This makes it a valuable tool in the development of new drugs with potential applications in treating various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (4-Iodo-pyridin-2-yl)-hydrazine is used as a key component in the creation of new agrochemicals. Its unique structure and properties allow for the development of innovative compounds that can be applied in agriculture to improve crop protection and yield.
Used in Fine Chemicals Synthesis:
(4-Iodo-pyridin-2-yl)-hydrazine is also utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its versatility in organic transformations makes it an essential component in the production of these high-quality chemicals.
Used in Drug Discovery:
(4-Iodo-pyridin-2-yl)-hydrazine is used as a starting material in drug discovery due to its potential to exhibit biological activity. Its unique structure allows researchers to explore its interactions with biological targets, potentially leading to the development of new therapeutic agents.
Used in Material Science:
In the field of material science, (4-Iodo-pyridin-2-yl)-hydrazine is used for the development of new materials with specific properties. Its versatile reactivity and unique structure make it an interesting candidate for creating materials with applications in various industries, such as electronics, coatings, and adhesives.
Used in Medicinal Chemistry Research:
(4-Iodo-pyridin-2-yl)-hydrazine is used as a research compound in medicinal chemistry to study its interactions with biological targets and its potential as a therapeutic agent. Its unique structure and properties make it an attractive candidate for further investigation in the development of new drugs and therapies.
Used in Chemical Biology:
In chemical biology, (4-Iodo-pyridin-2-yl)-hydrazine is used to explore its potential biological activities and its ability to modulate biological processes. This research can lead to a better understanding of the compound's role in biological systems and its potential applications in the development of new therapeutic strategies.

Upstream product

• 153034-86-7 2-chloro-4-iodopyridine 
• 22282-70-8 2-fluoro-4-iodopyridine 

Downstream Products

• 1456505-28-4 (S)-5,5-dimethyl-4-phenyl-3-(4-(7-(pyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)phenyl)oxazolidin-2-one 
• 1456505-29-5 (S)-3-(4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)phenyl)-[1,2,4]triazolo[4,3-a]pyridine-7-carbonitrile 
• 1456506-60-7 (S)-3-(4-(7-iodo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one 
• 864866-44-4 7-iodo-[1,2,4]triazolo[4,3-a]pyridine 
• 1019918-15-0 N-cyclopropyl-3-(3-(1,1-dimethylethyl)[1,2,4]triazolo-[4,3-a]pyridin-7-yl)-4-methylbenzamide 
• 1456506-61-8 (S)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)-N'-(4-iodopyridin-2-yl)benzohydrazide 
• 1268883-41-5 (1aR,5aR)-2-(4-fluoro-pyridin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid 
• 1268883-40-4 (1aR,5aR)-2-(4-iodo-pyridin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid 
• 1268883-19-7 (1aR,5aR)-2-(4-iodo-pyridin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ethyl ester 
• 1375801-55-0 C₉H₁₀IN₃O 
• 1375801-59-4 C₁₂H₉ClIN₃O 
• 1057394-11-2 N-cyclopropyl-3-(3-cyclopropyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-5-fluoro-4-methylbenzamide 
• 1019917-79-3 N-cyclopropyl-3-(3-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-4-methylbenzamide 
• 1057394-12-3 N-cyclopropyl-3-fluoro-5-(3-isopropyl[1,2,4]triazolo[4,3-a]pyridin-7-yl)-4-methylbenzamide 

Relevant articles and documents

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

HISTONE DEMETHYLASE INHIBITORS

The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.

OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF

Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors

A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.

CANNABINOID RECEPTOR MODULATORS

Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor.

NEW 7-PHENYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3(2H)-ONE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to processes for their preparation, to pharmaceutical compositions comprising them, and to their use in therapy.

New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), to pharmaceutical compositions comprising them, and to their use in therapy.

NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.