22282-70-8

Basic information

• Product Name: 2-Fluoro-4-iodopyridine
• Synonyms: 4-Iodo-2-fluoropyridine;2-Fluoro-4-iodopyridine AldrichCPR;2-FLUORO-4-IODOPYRIDINE
• CAS NO: 22282-70-8
• Molecular Formula: C₅H₃FIN
• Molecular Weight: 222.99
• Product Categories: pharmacetical;Pyridine series;Heterocycle;Pyridines;Boronic Acid;Propidium heterocyclic series;NULL;Fluorine series;alkyl Iodine|alkyl Fluorine;Fluorin-contained pyridine series;Pyridine
• Mol File: 22282-70-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 57 °C
• Boiling Point: 223 °C at 760 mmHg
• Flash Point: 88.6 °C
• Appearance: Salmon-coloured solid
• Density: 2.046 g/cm³
• Vapor Pressure: 0.147mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Refrigerated.
• Solubility: soluble in Methanol
• PKA: -1.81±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Fluoro-4-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-iodopyridine(22282-70-8)
• EPA Substance Registry System: 2-Fluoro-4-iodopyridine(22282-70-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22282-70-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H3FIN/c6-5-3-4(7)1-2-8-5/h1-3H

Upstream product

• 128071-98-7 4-bromo-2-fluoropyridine 
• 168428-74-8 2-fluoro-4-iodo-3-pyridyllithium 
• 372-48-5 2-fluoropyridine 
• 113975-22-7 2-fluoro-3-iodopyridine 

Downstream Products

• 361147-25-3 2-chloro-4-(2-fluoropyridin-4-yl)pyrimidine 
• 896155-81-0 2-(benzyloxy)-4-iodopyridine 
• 950918-49-7 (2-fluoro-pyridin-4-yl)-(2-methoxy-phenyl)-methanol 
• 950918-50-0 (2-fluoro-pyridin-4-yl)-m-tolyl-methanol 
• 950918-48-6 (2-fluoro-pyridin-4-yl)-phenyl-methanol 
• 681262-23-7 2-fluoro-4-pent-1-ynylpyridine 
• 552331-00-7 4-(iodo)pyridin-2-amine 
• 864757-87-9 4-iodo-2-(4-methoxybenzyloxy)pyridine 
• 1239969-48-2 N-(2-fluoropyridin-4-yl)-4-phenylthiazol-2-amine 
• 1239969-43-7 2-fluoro-N-[4-(4-morpholinyl)phenyl]pyridin-4-amine 
• 1239969-38-0 2-fluoro-N-(2-methoxyphenyl)pyridin-4-amine 
• 1239969-39-1 N-(4-chlorophenyl)-2-fluoropyridin-4-amine 
• 1239969-37-9 2-fluoro-N-(4-methoxyphenyl)pyridin-4-amine 
• 1239969-45-9 2-fluoro-N-(4-methoxybenzyl)pyridin-4-amine 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

ANTIVIRAL COMPOUNDS

The present invention relates to a compound of formula: (I) or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.