Chemistry and pharmacology of homologs of 6 acetyl and 3,6 diacetylmorphine
3.6 Diformyl and 3,6 dipropanoylmorphine and 6 formyl and 6 propanoylmorphine were prepared to obtain longer acting, heroin like compounds. The 6 acylated compounds were more potent than heroin subcutaneously and were orally effective, and their duration of action was at least two to three times greater than that of heroin in monkey species.
Syntheses of 3-O- and 6-O-propanoylmorphine: A reinvestigation and correction
3-O-Propanoylmorphine was obtained using the conditions reported earlier for the specific synthesis of 6-O-propanoylmorphine. The latter isomer was synthesized using two different methods; the two compounds were authenticated using IR, MS, carbon-13 and proton NMR.
Sy,By,Neville,Wilson
p. 787 - 789
(2007/10/02)
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