Journal of Pharmaceutical Sciences p. 285 - 286 (1977)
Update date:2022-08-29
Topics:
May
Jacobson
3.6 Diformyl and 3,6 dipropanoylmorphine and 6 formyl and 6 propanoylmorphine were prepared to obtain longer acting, heroin like compounds. The 6 acylated compounds were more potent than heroin subcutaneously and were orally effective, and their duration of action was at least two to three times greater than that of heroin in monkey species.
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