106014-21-5Relevant articles and documents
Selective alkoxycarbonylation of 2,3-dichloropyridines
Bessard, Yves,Roduit, Jean Paul
, p. 393 - 404 (1999)
2,3-Dichloropyridines undergo a motto- or a dicarbonylation in the presence of carbon monoxide, an alcohol and a palladium catalyst, affording selectively either alkyl 3-chloropicolinates, or dialkyl pyridine-2,3- dicarboxylates in good yields, depending on the reaction conditions.
SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS
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Page/Page column 111-112, (2009/04/25)
Disclosed are compounds of formula (I) which are bradykinin B1 receptor (B1R) antagonists. These compounds are useful to treat diseases or relieve adverse symptoms associated with inflammation and pain. The invention encompasses novel compounds and acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases involving inflammation and pain.
A New Synthesis of Lysergic Acid
Hendrickson, James B.,Wang, Jian
, p. 3 - 5 (2007/10/03)
(Equation presented) (±)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
Process for preparing pyridinecarboxylic esters
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, (2008/06/13)
A process for preparing pyridinecarboxylic esters of the general formula: wherein R1 is hydrogen, a C1-6-alkyl group, a C1-4-alkoxycarbonyl group, a C1-4-alkoxymethyl group or a fluorinated C1-6-alkyl group, R2 is a C1-4-alkyl group and X is chlorine or bromine. The pyridinecarboxylic esters are obtained by reacing the corresponding 2,3-dihalopyridines with carbon monoxide and a C1-4-alkanol in the presence of a weak base and a complex of palladium with a bis(diphenylphosphine). Pyridinecarboxylic esters are intermediates for preparing herbicides and drugs against fibrotic diseases.
Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals
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, (2008/06/13)
Sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation, and their use as pharmaceuticals The invention relates to sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides according to the formul
Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals
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, (2008/06/13)
The invention relates to sulfonamidocarbonylpyridine-2-carboxesteramides and their pyridine-N-oxides according to the formula I STR1 Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline h
SUBSTITUTED HETEROCYCLIC CARBOXAMIDE ESTERS, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
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, (2008/06/13)
The invention relates to compounds of the formula I, to a process for their preparation and to their use as pharmaceuticals. The compounds are employed, in particular, as ester prodrugs of prolyl hydroxylase inhibitors for inhibiting collagen biosynthesis and as fibrosuppressive agents