106018-98-8

Basic information

• Product Name: Benzenemethanol, a-(1-bromo-1-chloro-2,2,2-trifluoroethyl)-
• CAS NO: 106018-98-8
• Molecular Formula: C9H7BrClF3O
• Molecular Weight: 303.506
• Mol File: 106018-98-8.mol

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(1-bromo-1-chloro-2,2,2-trifluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(1-bromo-1-chloro-2,2,2-trifluoroethyl)-(106018-98-8)
• EPA Substance Registry System: Benzenemethanol, a-(1-bromo-1-chloro-2,2,2-trifluoroethyl)-(106018-98-8)

Safety Data

• Hazardous Substances Data: 106018-98-8(Hazardous Substances Data)

Upstream product

• 754-17-6 1-chloro-1,1-dibromotrifluoroethane 
• 100-52-7 benzaldehyde 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 

Downstream Products

• 34091-69-5 (2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 

Relevant articles and documents

A method for synthesis of fluorine compounds using abnormal Grignard reaction of halothane. II. Reaction with aldehydes and unsaturated ketones

In an abnormal Grignard reaction of halothane, the primary Grignard reagent reacts with another mole of halothane to give 1-bromo-1-chloro- 2,2,2-trifluoroethylmagnesium bromide, which in turn reacts with a carbonyl compound to give 1-bromo-1-chloro-2,2,2

Synthesis of fluorine compounds using zinc complex of halothane

We have reported the Grignard reaction of Halothane, 2-bromo-2-chloro-1,1,1-trifluoroethane (1), with ketones gave unexpected products, α-(1-bromo-1-chloro-2,2,2-trifluoroethyl)alcohols (4) at a low temperature. However, this reaction hardly proceeded with aldehydes. Now, we found the reaction of 1 with aldehydes in the presence of zinc gave not only products of type 4, but α-(1-chloro-2,2,2-trifluoroethyl)alcohols (3), the expected type of products, under mild conditions in good to moderate yields.

Efficient Carbonyl Addition of Polyfluorochloroethyl, -ethylidene, and -ethenyl Units by Means of 1,1,1-Trichloro-2,2,2-trifluoroethane and Zinc

Thermally stable zinc carbenoid CF3CCl2ZnCl was prepared from 1,1,1-trichloro-2,2,2-trifluoroethane and zinc powder in N,N-dimethylformamide and was allowed to add to carbonyls of aldehydes and α-keto esters in excellent yields to give 1-substituted 2,2-d

EFFICIENT CARBON-CARBON BOND FORMATION WITH THERMALLY STABLE 1,1-DIHALO-2,2,2-TRIFLUOROETHYLZINC REAGENT

The zinc carbenoids CF3CX2ZnX, prepared from CF3CX3 and zinc powder in dimethylformamide, were found thermally stable to add to aldehyde carbonyls in excellent yields.