100-52-7

Basic information

• Product Name: Benzaldehyde
• Synonyms: Benzaldehyde (natural);Artificial essential oil of almond;Oil Of bitter almond;Benzenecarbonal;Benzaldehyde (NF);Artificial Almond Oil;Benzoic aldehyde;Benzadehyde;Phenylmethanal;Benzenecarboxaldehyde;Benzene carbaldehyde;Benzene carboxaldehyde;Synthetic oil of bitter almond;Bitter almond oil, synthetic;Benzenemethylal;benzanoaldehyde;Benzaldehyde , Natural;Natural Benzaldehyde;Benzaldehyde nat.;Benzal dehyde;Benzenecarbaldehyde
• CAS NO: 100-52-7
• Molecular Formula: C₇H₆O
• Molecular Weight: 106.12194
• EINECS: 202-860-4
• Mol File: 100-52-7.mol
• Article Data: 6640

Chemical Properties

• Melting Point: -26℃
• Boiling Point: 178.7 °C at 760 mmHg
• Flash Point: 62.8 °C
• Appearance: colorless liquid
• Density: 1.049 g/cm³
• Vapor Density: 3.65
• Vapor Pressure: 0.974mmHg at 25°C
• Refractive Index: 1.566
• Water Solubility: <0.01 g/100 mL at 19.5℃
• CAS DataBase Reference: Benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde(100-52-7)
• EPA Substance Registry System: Benzaldehyde(100-52-7)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Safety Statements: S24:
• Hazardous Substances Data: 100-52-7(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion andintraperitoneal routes. Moderately toxic by subcutaneousroute. An allergen. Acts as a feeble local anesthetic. Localcontact may cause contact dermatitis. Causes centralnervous system depression in small doses and convulsionsin

InChI:InChI=1/C7H6O/c8-6-7-4-2-1-3-5-7/h1-6H

Synthetic route

styrene (292638-84-7) → benzaldehyde (100-52-7)

Conditions	Yield
With sodium periodate; C31H29Br2N3Ru*CH2Cl2 In water; ethyl acetate; acetonitrile at 25℃; for 0.5h; Activation energy; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique;	100%
With ruthenium trichloride; [bis(acetoxy)iodo]benzene In dichloromethane; water at 30℃; for 1.5h; Catalytic behavior; Reagent/catalyst; Solvent;	99.8%
With sodium periodate; C22H23ClIN2Os(1+)*F6P(1-) In water; tert-butyl alcohol at 60℃; Catalytic behavior; Reagent/catalyst; Schlenk technique; Inert atmosphere;	97%

stilbene (588-59-0) → benzaldehyde (100-52-7)

Conditions	Yield
With oxygen In dichloromethane at 20℃; for 2h; visible light irradiation;	100%
With sodium periodate; [η5-C5H5Ru(CO)2NH2C6H11]BF4 In water; acetonitrile at 60℃; for 1h; Catalytic behavior; Schlenk technique; Inert atmosphere;	100%
With dihydrogen peroxide In acetonitrile at 65℃; for 6h;	96%

MANDELIC ACID (611-71-2, 611-72-3, 17199-29-0, 90-64-2) → benzaldehyde (100-52-7)

Conditions	Yield
With dinitratocerium (IV) chromate In benzene for 0.666667h; Heating;	100%
With tris paraperiodate In benzene for 1.5h; Heating;	100%
With pyridine chromium peroxide In dichloromethane for 0.25h; Product distribution; Ambient temperature; effect of various chromium(VI) based oxidants;	100%

toluene (108-88-3) → benzaldehyde (100-52-7)

Conditions	Yield
With laccase from Coriolus versicolor MTCC-138; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt In 1,4-dioxane for 0.5h; pH=4.5; Green chemistry; Enzymatic reaction;	100%
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Reagent/catalyst; Solvent; Irradiation; Green chemistry;	98%
With water at 20℃; for 3h; Reagent/catalyst;	98%

benzylamine (100-46-9) → benzaldehyde (100-52-7)

Conditions	Yield
With dinitratocerium (IV) chromate In benzene for 1.25h; Heating;	100%
With 2,2'-bipyridylchromium peroxide for 0.4h; Product distribution; effect of various chromium(VI) based oxidants;	100%
With barium ferrate(VI) In benzene for 1h; Product distribution; Heating;	100%

benzyl alcohol (100-51-6) → benzaldehyde (100-52-7)

Conditions	Yield
With bis(pyridine)silver(I) permanganate In benzene for 0.5h;	100%
With pyridine chromium peroxide In dichloromethane for 0.5h; Ambient temperature;	100%
With manganese(IV) oxide; Pyridine-2,6-dicarboxylic acid In water; acetonitrile at 20℃; for 20h;	100%

cyclohexene sulfide (286-28-2) + cis-2-methyl-3-phenyloxaziridine (39245-63-1) → (Z)-azomethane (4143-42-4) + N,N'-bis(methyl)sulphur di-imide (13849-02-0, 84878-02-4, 84878-03-5, 84878-04-6) + benzaldehyde (100-52-7) + cyclohexene (110-83-8)

Conditions	Yield
In chloroform Mechanism; Ambient temperature; via thionitrosomethane, CH3NS (also used: other oxaziridines and episulfides);	A n/a B 83% C 100% D 100%

(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)(phenyl)methanone (19202-00-7) → 1,4-benzoxazine (5735-53-5) + benzaldehyde (100-52-7)

Conditions	Yield
With sodium bis(2-methoxyethoxy)aluminium dihydride In ethyl acetate; benzene at -40℃;	A 100% B 100%

2-phenyl-1,3-dioxolane (936-51-6) → benzaldehyde (100-52-7)

Conditions	Yield
1,3-di(NCS)-tetrabutyldistannoxane In diethylene glycol dimethyl ether; water at 100℃; for 2h; Deprotection of acetal;	100%
Tetrabutyl-1,3-diisothiocyanato-distannoxane In diethylene glycol dimethyl ether; water at 100℃; for 2h;	100%
With 4-phenyl-2,2,5,5-tetramethyl-3-imidazolin-1-yloxy-3-oxide; 15-crown-5; KCrO5Cl In acetonitrile at 60℃; for 7h; Product distribution; Further Variations:; Reagents;	100%

phenylethane 1,2-diol (93-56-1) + 4-cyano-N,N-dimethylaniline-N-oxide (62820-00-2) → formaldehyd (50-00-0) + 4-cyano-N-methylaniline (4714-62-9) + benzaldehyde (100-52-7) + 4-cyano-N,N-dimethylaniline (1197-19-9)

Conditions	Yield
With chloro(5,10,15,20-tetraphenylporphyrinato)chromium(III) In acetonitrile for 0.666667h; Rate constant; Ambient temperature; Irradiation; oxygen transfer was investigated, different irradiation time;	A n/a B n/a C 100% D 100%

phenylethane 1,2-diol (93-56-1) → benzaldehyde (100-52-7)

Conditions	Yield
With tris paraperiodate In benzene for 1.5h; Heating;	100%
With N-iodo-succinimide In tetrahydrofuran for 3h; Ambient temperature; in the dark;	98%
With calcium hypochlorite; water; aluminum oxide for 0.00555556h; microwave irradiation;	98%

2-Phenyl-[1,3]dithiane (5425-44-5) → benzaldehyde (100-52-7)

Conditions	Yield
With K-10 clay supported copper(II) nitrate trihydrate In dichloromethane for 5h; Ambient temperature; K-10 clay supported iron(III) nitrate nonahydrate; mild cleavege of thioacetals into the corresponding carbonyl compounds;	100%
With K-10 clay supported iron(III) nitrate nonahydrate In dichloromethane for 5h; Ambient temperature; with K-10 clay-supported copper(II) nitrate trihydrate;	100%
With dihydrogen peroxide; iodine; sodium dodecyl-sulfate In water at 20℃; for 0.75h; Micellar solution;	100%

(E)-1,2-diphenyl-ethene (103-30-0) → benzaldehyde (100-52-7)

Conditions	Yield
With 1,2,3,4,5-pentafluoro-6-iodosylbenzene; iron(III) perchlorate In acetonitrile at -10℃; for 0.0833333h;	100%
With air; [Pt(2,2':6',2'':6'',2'''-quaterpyridine)](CF3SO3)2; Nafion In acetonitrile at 20℃; for 5h; Irradiation;	100%
With sodium periodate; osmium(VIII) oxide In tetrahydrofuran; water at 20℃;	99%

(2-methyl-1-propenyl)-benzene (768-49-0) → benzaldehyde (100-52-7)

Conditions	Yield
With sodium nitrite In water; acetic acid 1.) 0 deg C 2.) 60 deg C, 0,5 h;	100%
With oxygen at 25℃; under 1500.15 Torr; for 24h; pH=6; aq. buffer; Enzymatic reaction; chemoselective reaction;

benzyloxy-trimethylsilane (14642-79-6) → benzaldehyde (100-52-7)

Conditions	Yield
With benzyltriphenylphosphonium chlorate; aluminium trichloride In acetonitrile for 0.25h; Heating;	100%
With nitrogen dioxide at 20℃; for 0.0833333h;	100%
With N-benzyl-N,N-dimethyl anilinium peroxodisulfate In acetonitrile for 0.0833333h; Reflux;	99%

(diethoxymethyl)benzene (774-48-1) → benzaldehyde (100-52-7)

Conditions	Yield
With water at 80℃; for 2h;	100%
With iodo trichloro silane for 0.333333h; Ambient temperature;	95%
With iodo trichloro silane for 0.333333h; Product distribution; Mechanism; Ambient temperature; other acyclic and cyclic acetals and ketals;	95%

benzaldehyde p-toluenesulfonylhydrazone (1666-17-7) → benzaldehyde (100-52-7)

Conditions	Yield
With copper(II) sulfate In tetrahydrofuran; methanol; water for 24h; Heating;	100%
With Cr-MCM-41 zeolite on silica gel for 0.1h; microwave irradiation;	96%
With copper(II) nitrate In tetrachloromethane at 25℃; for 2h; regeneration of aldehydes and ketones from tosylhydrazones; further tosylhydrazones;	92%

benzyl nitrite (935-05-7) → benzaldehyde (100-52-7)

Conditions	Yield
With nitric acid In dichloromethane at 20℃; for 1h;	100%
With sulfuric acid In dichloromethane; water for 0.5h; in air;	100%
With dimethyl sulfoxide at 70℃; for 6h;	87.9%
With Amberlyst-15 In 1,4-dioxane at 40℃; Kinetics; Concentration; Temperature;

benzaldehyde dimethyl acetal (1125-88-8) → benzaldehyde (100-52-7)

Conditions	Yield
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In water at 30℃; for 0.0833333h;	100%
With water at 80℃; for 2h;	100%
With water at 90℃; Inert atmosphere;	100%

benzylidene 1,1-diacetate (581-55-5) → benzaldehyde (100-52-7)

Conditions	Yield
With [NO(1+)*18-crown-6*H(NO3)2(1-)]; silica gel In dichloromethane at 20℃; for 0.0833333h;	100%
With sulphated zirconia In acetonitrile at 60℃; for 0.45h; Microwave irradiation;	100%
With aluminum oxide at 35℃; for 0.0111111h; microwave irradiation;	98%

benzaldehyde dibenzyldithioacetal (5418-20-2) → dibenzyl disulphide (150-60-7) + benzaldehyde (100-52-7)

Conditions	Yield
With hydrogenchloride; sodium nitrate In tetrachloromethane; water for 5h; Ambient temperature; other reagent;	A n/a B 100%

1-(N,N-dibenzylamino)cyclopropanecarboxylic acid (119111-63-6) → benzaldehyde (100-52-7) + 1-(N-benzylamino)cyclopropanecarboxylic acid hydrochloride (119111-75-0)

Conditions	Yield
With pivaloyl chloride In chloroform Ambient temperature;	A 100% B 63%

benzaldehyde semicarbazone (1574-10-3) → benzaldehyde (100-52-7)

Conditions	Yield
With Oxone; silica gel In dichloromethane for 0.333333h; Reflux;	100%
With benzyltriphenylphosphonium dichromate; silica gel for 0.166667h;	97%
With hexaaquairon(III) perchlorate for 2h;	96%

1-Acetamido-N-benzyloxy-6,7-dihydro-5H-dibenzazepin (83080-95-9) → benzaldehyde (100-52-7) + 1-Acetamido-5H-dibenzazepin-N-oxid (83081-01-0) + 11-Acetamido-5H-dibenzazepin-N-oxid (83081-02-1)

Conditions	Yield
With dihydrogen peroxide In acetic acid for 1.66667h; Ambient temperature; Yield given. Title compound not separated from byproducts;	A 100% B n/a C n/a

benzaldehyde phenylhydrazone (588-64-7) → benzaldehyde (100-52-7)

Conditions	Yield
With copper(II) sulfate In tetrahydrofuran; methanol; water for 6h; Heating;	100%
With baker's yeast; phosphate buffer In ethanol at 37℃; for 12h;	98%
With CuCl*Kieselghur; oxygen In dichloromethane at 20℃; for 0.416667h;	98%

tetrahydro-2-(benzyloxy)-2H-pyran (1927-62-4) → benzaldehyde (100-52-7)

Conditions	Yield
With aluminium trichloride; benzyltriphenylphosphonium chlorate In acetonitrile at 20℃; for 3h;	100%
With aluminium trichloride; tetramethylammonium chlorochromate In acetonitrile for 0.75h; Heating;	98%
With β‐cyclodextrin; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water; acetone at 20℃; for 1h;	96%

2-hydroxy-1,2,3-triphenyl-propan-1-one (7540-93-4) → phenyl benzyl ketone (451-40-1) + 2-hydroxy-2-phenylacetophenone (119-53-9) + benzaldehyde (100-52-7)

Conditions	Yield
With tetra-n-butylammonium cyanide In tetrahydrofuran for 1h; Heating;	A 100% B 38% C 6%

α-(2-cyanoethyl)benzoin (174869-02-4) → 4-oxo-4-phenylbutanenitrile (5343-98-6) + 2-hydroxy-2-phenylacetophenone (119-53-9) + benzaldehyde (100-52-7)

Conditions	Yield
With tetra-n-butylammonium cyanide In tetrahydrofuran for 1h; Ambient temperature;	A 100% B 75% C 2%

2-phenyl-1,3-dioxane (772-01-0) → benzaldehyde (100-52-7)

Conditions	Yield
With 4-phenyl-2,2,5,5-tetramethyl-3-imidazolin-1-yloxy-3-oxide; 15-crown-5; KCrO5Cl In acetonitrile at 60℃; for 7h; Product distribution; Further Variations:; Reagents;	100%
indium(III) chloride In methanol; water for 1.16667h; Heating;	93%
With water; sodium acetate; Pyridine hydrobromide In methanol at 20℃; for 24h; Reagent/catalyst;	9%

4-chloromethyl-2-phenyl[1,3]dioxolane (36236-72-3) → benzaldehyde (100-52-7)

Conditions	Yield
With 4-phenyl-2,2,5,5-tetramethyl-3-imidazolin-1-yloxy-3-oxide; 15-crown-5; KCrO5Cl In acetonitrile at 60℃; for 7h; Product distribution; Further Variations:; Reagents;	100%

piperidine (110-89-4) + benzaldehyde (100-52-7) → 1,1'-benzylidenedipiperidine (2538-76-3)

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0333333h;	100%
In ethanol at 25℃; for 0.5h;	95%
With aluminum oxide In diethyl ether at 20℃;	90%

morpholine (110-91-8) + benzaldehyde (100-52-7) → 4,4'-(phenylmethylene)bismorpholine (6425-08-7)

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0333333h;	100%
In benzene at 20℃; for 16h; Inert atmosphere;	99%
In benzene Reflux;	95%

2-methyl-1H-indole (95-20-5) + benzaldehyde (100-52-7) → 2-methyl-3-((2-methyl-1H-indol-3-yl)(phenyl)methyl)-1H-indole (17371-59-4)

Conditions	Yield
With C62H58N8O20Y2Zn2 In ethanol; water for 2h; Friedel-Crafts Alkylation;	100%
With tris(hydroxymethyl)methane ammonium hydrogensulphate In neat (no solvent) at 20℃; for 0.0833333h; Green chemistry;	99%
With ruthenium trichloride In methanol at 20℃; for 0.05h;	98%

N-methyl-N-(pyridin-2-yl)hydrazine (4231-74-7) + benzaldehyde (100-52-7) → (E)-2-benzylidene-1-methyl-1-(pyridin-2-yl)hydrazine (4231-75-8)

Conditions	Yield
In ethanol for 6h; Reflux;	100%
With water

2-oxoindole (59-48-3) + benzaldehyde (100-52-7) → 3-benzylideneoxindole (3359-49-7, 23772-61-4, 23782-37-8)

Conditions	Yield
With UiO-66 metal organic framework nanoparticles In neat (no solvent) at 80℃; for 2h; Friedel-Crafts Alkylation; Sealed tube; Darkness;	100%
With pyrrolidine In ethanol for 2h; Reflux;	94%
With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate at 80℃; for 1h;	93%

4-aminourazole (21531-96-4) + benzaldehyde (100-52-7) → 4-benzylidenamino-[1,2,4]triazolidine-3,5-dione (4114-10-7)

Conditions	Yield
In water for 0.5h; Reflux;	100%
With water

isobutylamine (78-81-9) + benzaldehyde (100-52-7) → benzylideneisobutylamine (27845-49-4, 6852-57-9)

Conditions	Yield
at 20℃; for 2h;	100%
	91%

cyclohexanone (108-94-1) + benzaldehyde (100-52-7) → 2-Benzylidenecyclohexanone (5682-83-7)

Conditions	Yield
Stage #1: cyclohexanone With sodium hydroxide In ethanol; water at 0 - 5℃; Stage #2: benzaldehyde In ethanol; water	100%
With CaO modified with benzyl bromide In methanol at 65℃; under 760.051 Torr; for 3h; Reagent/catalyst; Concentration; Temperature; Time;	95.8%
With N,N-Dimethyltrimethylsilylamine; magnesium bromide ethyl etherate at 20℃; for 16h; Inert atmosphere; neat (no solvent);	93%

acetic anhydride (108-24-7) + benzaldehyde (100-52-7) → benzylidene 1,1-diacetate (581-55-5)

Conditions	Yield
With poly(4-vinylpyridine)-supported sulfuric acid In dichloromethane at 20℃; for 0.25h; Green chemistry; chemoselective reaction;	100%
With SBA-15-Ph-PrSO3H at 20℃; for 0.0833333h; Green chemistry;	100%
With poly(4-vinylpyridinium) perchlorate In neat (no solvent) at 20℃; for 0.0333333h; Time; Green chemistry; chemoselective reaction;	100%

ethyl acetoacetate (141-97-9) + benzaldehyde (100-52-7) + urea (57-13-6) → ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate (123237-03-6, 5395-36-8)

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1h; Biginelli reaction; Microwave irradiation; Inert atmosphere;	100%
With Cl7Fe2(1-)*C6H9N2O2(1+); C8H15N2(1+)*C4H12B(1-) at 80℃; for 2h; Reagent/catalyst; Biginelli Pyrimidone Synthesis;	99%
With guanidine In neat (no solvent) at 80℃; for 2h; Biginelli Pyrimidone Synthesis;	99%

ethyl acetoacetate (141-97-9) + benzaldehyde (100-52-7) → Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate (1165-06-6)

Conditions	Yield
With ammonia for 3h; Heating;	100%
With C23H3BF16N2O; ammonium acetate In toluene at 100℃; for 10h; Hantzsch Dihydropyridine Synthesis;	100%
With ammonium carbonate In water at 55 - 60℃; for 3.5h; Hantzsch pyridine synthesis;	99%

1-amino-naphthalene (134-32-7) + benzaldehyde (100-52-7) → N-benzylidenenaphthalen-1-amine (890-51-7)

Conditions	Yield
With aluminum oxide for 5h; Milling;	100%
In water at 20℃; for 2h;	80%
In dichloromethane for 10h; Reflux;	70%

1.3-propanedithiol (109-80-8) + benzaldehyde (100-52-7) → 2-Phenyl-[1,3]dithiane (5425-44-5)

Conditions	Yield
With boron trifluoride diethyl etherate at 23℃; for 3h;	100%
With lithium tetrafluoroborate at 25℃; for 1h;	100%
With lithium bromide at 75 - 80℃; for 0.25h;	99%

propylamine (107-10-8) + benzaldehyde (100-52-7) → N-benzylidenepropylamine (6852-55-7)

Conditions	Yield
In toluene for 1h; Ambient temperature;	100%
at 26℃; for 24h;	96%
With aluminum oxide at 20℃; for 4h;	95%

n-butyllithium + benzaldehyde (100-52-7) → 1-Phenyl-1-pentanol (583-03-9)

Conditions	Yield
In tetrahydrofuran; hexane at -78 - 20℃;	100%
Stage #1: n-butyllithium With mischmetall tribromide In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: benzaldehyde In tetrahydrofuran; hexane at -78℃; for 3h; Imamoto reaction;	98%
In hexane at -78 - 20℃; for 1.16667h;	95%

nitromethane (75-52-5) + benzaldehyde (100-52-7) → 2-nitro-1-phenylethan-1-ol (141377-54-0, 145920-96-3, 149495-00-1, 15990-45-1)

Conditions	Yield
palladium/alumina at 60℃; for 1h;	100%
With 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide In neat (no solvent) at 20℃; for 0.166667h; Reagent/catalyst; Henry Nitro Aldol Condensation; Green chemistry;	99%
With 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide In neat (no solvent) at 20℃; for 0.166667h; Catalytic behavior; Reagent/catalyst; Henry Nitro Aldol Condensation; Ionic liquid; Green chemistry;	99%

hydrogen cyanide (74-90-8) + benzaldehyde (100-52-7) → (R)-Mandelonitrile (10020-96-9)

Conditions	Yield
With (R)-oxynitrilase (almond meal); citric buffer pH 5.5 In ethyl acetate at 4℃; for 48h; Product distribution; other aldehydes and methyl ketones, also in micro-aqueous phase, var temp. and solvents;	100%
With (R)-oxynitrilase (almond meal) In ethyl acetate at 4℃; for 48h; 0.02 M citrate buffer pH 5.5;	100%
With (R)-hydroxynitrile lyase In tert-butyl methyl ether; dimethyl sulfoxide at 5℃; for 24h; pH=4; aq. citrate buffer; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	100%

(R,R)-2,3-butandiol (24347-58-8) + benzaldehyde (100-52-7) → 4,5-dimethyl-2-phenyl-(2α,4α,5β)-1,3-dioxolane (75281-80-0)

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 100℃; for 3h; Molecular sieve;	100%
With trifluoromethanesulfonate; 1-phenyl-1-trimethylsilyloxyethane In dichloromethane at -20℃; for 3h;	96%
With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 140℃; for 2h;	85%

hexan-1-amine (111-26-2) + benzaldehyde (100-52-7)

Conditions	Yield
at 20℃; for 2h;	100%
With ethanol; potassium carbonate
With aluminum oxide for 2h; Ambient temperature;

+ benzaldehyde (100-52-7) → t-butyl 3-benzylidenecarbazate (24469-50-9)

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h;	100%
In ethanol for 3h; Reflux;	100%
In ethanol	99%

4,4'-thiobisaniline (139-65-1) + benzaldehyde (100-52-7) → N,N'-(thiobis(4,1-phenylene))bis(1-phenyl methanimine) (3430-68-0)

Conditions	Yield
With piperidine In ethanol	100%
With acetic acid In ethanol for 4h; Reflux;	86%
With ethanol; zinc(II) chloride

phenyl carbamate (64-10-8) + benzaldehyde (100-52-7) → 1,1'-(phenylmethylene)bis(3-phenylurea) (40848-82-6)

Conditions	Yield
In acetonitrile at 20℃; for 5h;	100%
With silica-bonded N-(propylsulfonyl)piperazine-N-sulfamic acid In toluene for 2.5h; Reflux;	78%

vinylmagnesium chloride (3536-96-7) + benzaldehyde (100-52-7) → 1-Phenyl-2-propen-1-ol (4393-06-0)

Conditions	Yield
In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;	100%
In tetrahydrofuran at -10 - 20℃; Schlenk technique;	95%
In tetrahydrofuran at -10℃; for 2h; Inert atmosphere;	93%

1-propynylmagnesium bromide (16466-97-0, 13254-27-8) + benzaldehyde (100-52-7) → 1-phenylbut-2-yn-1-ol (32398-66-6)

Conditions	Yield
In tetrahydrofuran	100%
In tetrahydrofuran at 0 - 20℃;	86%
In tetrahydrofuran at 0 - 20℃; for 2h; Grignard Reaction; Schlenk technique; Inert atmosphere;	77%

l-cysteine hydrochloride (52-89-1) + benzaldehyde (100-52-7) → (4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid (196930-46-8)

Conditions	Yield
Stage #1: l-cysteine hydrochloride With sodium hydroxide In water Stage #2: benzaldehyde In ethanol; water at 20℃; for 3h;	100%
With potassium acetate In methanol; water at 0 - 25℃; for 6h;	98%
Stage #1: l-cysteine hydrochloride With potassium carbonate In water Stage #2: benzaldehyde In methanol; water at 25℃; for 3h;	98%

ethylmagnesium bromide (925-90-6) + benzaldehyde (100-52-7) → 1-Phenyl-1-propanol (93-54-9)

Conditions	Yield
With methylaluminum bis(2,6-di-tert-butylphenoxide) In diethyl ether; toluene at -78℃; for 2h;	100%
In diethyl ether at 0 - 20℃;	87%
Stage #1: ethylmagnesium bromide; benzaldehyde In tetrahydrofuran at 30℃; for 24h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere;	73%

benzaldehyde (100-52-7) + 4-chloro-aniline (106-47-8) → N-(4-chlorobenzylidene)aniline (780-21-2)

Conditions	Yield
With acetic acid In 1,2-dichloro-ethane at 20℃; for 24h; Inert atmosphere;	100%
With aqueous extract of pericarp of Sapindus trifoliatus fruits at 20℃; for 0.0333333h;	98%
sodium hydrogen sulfate; silica gel at 62 - 64℃; for 0.0208333h; microwave irradiation;	96%

benzaldehyde (100-52-7) + dimedone (126-81-8) → 3,3,6,6-tetramethyl-9-phenyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8-(2H)-dione (19744-83-3)

Conditions	Yield
With poly[(2-acrylamido-2-methylpropane sulfonic acid)-co-(acrylic acid)-co-(vinyl functionalized halloysite clay)] In water at 20℃; for 3h;	100%
With sulfated polyborate catalyst In neat (no solvent) at 100℃; for 0.05h; Catalytic behavior; Temperature; Green chemistry;	99%
With acetic acid at 110℃; for 0.25h; Microwave irradiation;	98%

Upstream product

• 100-51-6 Benzyl alcohol 
• 8007-80-5 Cinnamon oil 
• 1314-13-2 Zinc oxide 
• 100-44-7 Benzyl chloride 
• 29883-15-6 Amygdalin 
• 497-19-8 Sodium carbonate 
• 10028-15-6 Ozone 
• 14371-10-9 trans-Cinnamaldehyde 

Downstream Products

• 12217-48-0 ASTRAZON BRILLIANT RED 4G 
• 487-26-3 FLAVANONE 
• 484-47-9 2,4,5-TRIPHENYLIMIDAZOLE 
• 2935-35-5 L-Phenylglycine 
• 1708-39-0 2-PHENYL-1.3-DIOXOLANE-4-METHANOL 
• 122-57-6 Benzalacetone 
• 125971-96-2 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide 
• 38235-77-7 (R)-(+)-N-Benzyl-1-phenylethylamine 
• 20570-96-1 BENZYLHYDRAZINE DIHYDROCHLORIDE 
• 298-83-9 Nitrotetrazolium blue chloride 
• 57-41-0 5,5-Diphenylhydantoin 
• 102-49-8 3,4-Dichlorobenzylamine 
• 21829-25-4 Nifedipine 
• 32005-36-0 Bis(dibenzylideneacetone)palladium 
• 82159-09-9 Epalrestat 
• 1202-04-6 Methyl 1H-indole-2-carboxylate 
• 1145-01-3 3,5-DIPHENYLPYRAZOLE 
• 40675-60-3 1-AMINO-4-METHYLPIPERAZINE DIHYDROCHLORIDE MONOHYDRATE 
• 30676-70-1 Benzenemethanol, ar-methyl-, acetate 
• 298-96-4 2,3,5-Triphenyltetrazolium chloride 
• 3160-35-8 4-Hydroxybenzylideneacetone 
• 2650-18-2 Acid Blue 9 
• 7039-50-1 2-amino-5-chloro-diphenyl methanol 
• 122-75-8 N,N'-Dibenzyl ethylenediamine diacetate 
• 15595-35-4 L-Arginine hydrochloride 
• 34183-22-7 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride 
• 939-90-2 TRANS-2-PHENYL-1-CYCLOPROPANECARBOXYLIC ACID 
• 6104-58-1 Acid Blue 90 
• 61951-74-4 Reactive Blue 104 
• 101-86-0 alpha-Hexylcinnamaldehyde 
• 6311-48-4 N,N'-BISBENZYLIDENEBENZIDINE 
• 51364-51-3 Tris(dibenzylideneacetone)dipalladium 
• 5469-45-4 2-(Acetylamino)-3-phenyl-2-propenoic acid 
• 611-72-3 DL-Mandelic acid 
• 5355-16-8 Diaveridine 
• 14426-28-9 Magentagreencrystals 

Recommend Products

• 98-86-2  acetophenone 
• 186581-53-3  diazomethane 
• 60-29-7  diethyl ether 
• 56485-04-2  benzylglyoxal 
• 1638-63-7  2-acetoxy-2-phenylacetyl chloride 
• 62-53-3  aniline 
• 78-93-3  butanone 
• 110-89-4  piperidine 
• 732-68-3  5-[(phenyl)(phenylamino)]pentan-3-one 
• 141-97-9  ethyl acetoacetate 
• 117226-89-8  2-acetyl-4-cyano-3-phenyl-glutaramic acid ethyl ester 
• 64-17-5  ethanol 
• 107-91-5  cyanoacetic acid amide 
• 620-80-4  ethyl 2-benzylidene acetoacetate 

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