- MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS
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The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.
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- Preparation method of 3-bromo-6-methyl-2-pyridylaldehyde
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The invention relates to a preparation method of 3-bromo-6-methyl-2-pyridylaldehyde. The 3-bromo-6-methyl-2-pyridylaldehyde is an important medical intermediate and has wide market prospects. The 3-bromo-6-methyl-2-pyridylaldehyde can be condensed with amino groups to form an N-containing Schiff alkali conjugated system; and both N atoms on the pyridine ring and N atoms on imino C=N outside the ring can be coordinated with metal ions to form functional complexes. The preparation method comprises the following step: by using 5-bromo-2-methylpyridine as an initial raw material, carrying out N-oxidation, cyanation, acidification, esterification, reduction and aldehyde reaction to obtain the product 3-bromo-6-methyl-2-pyridylaldehyde. The 3-bromo-6-methyl-2-pyridylaldehyde synthesized by the method has the advantages of high purity, high yield and lower production cost. The synthesis method is simple and easy to implement, is green and environment-friendly, and provides theoretical and experimental references for industrial production.
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