126325-46-0

Basic information

• Product Name: 2-Amino-3-bromo-6-methylpyridine
• Synonyms: TIMTEC-BB SBB005516;2-AMINO-3-BROMO-6-METHYLPYRIDINE;2-AMINO-3-BROMO-6-PICOLINE;3-BROMO-6-METHYLPYRIDIN-2-AMINE;3-BROMO-6-METHYL-PYRIDIN-2-YLAMINE;6-AMINO-5-BROMO-2-PICOLINE;BUTTPARK 43\57-93;2-AMINO-3-BROMO-6-PICOLINE (2-AMINO-3-BROMO-6-METHYLPYRIDINE)
• CAS NO: 126325-46-0
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• Product Categories: compounds of pyridine;Pyridine;Amines;Pyridines;Pyridines derivates;Boronic Acid
• Mol File: 126325-46-0.mol

Chemical Properties

• Melting Point: 77-79°C
• Boiling Point: 238.5 °C at 760 mmHg
• Flash Point: 98.1 °C
• Appearance: Off-white/Solid
• Density: 1.5672 (rough estimate)
• Vapor Pressure: 0.0422mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Keep Cold
• PKA: 4.24±0.50(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Amino-3-bromo-6-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-6-methylpyridine(126325-46-0)
• EPA Substance Registry System: 2-Amino-3-bromo-6-methylpyridine(126325-46-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• HazardClass: 6.1
• Hazardous Substances Data: 126325-46-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

InChI:InChI=1/C6H7BrN2/c1-4-2-3-5(7)6(8)9-4/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 91872-10-5 2-amino-3,5-dibromo-6-methylpyridine 

Downstream Products

• 135995-44-7 N-(3-bromo-6-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 
• 1286273-54-8 6-methyl-3-morpholinopyridin-2-amine 
• 1609373-95-6 3-(2,3-dimethoxyphenyl)-6-methylpyridin-2-amine 
• 1609373-98-9 2-methylbenzofuran[2,3-b]pyridin-8-yl-trifluoromethanesulfonate 
• 1609373-99-0 1,2-methyl-8-(2-pyridine)benzofuran[2,3-B]pyridine 
• 875051-72-2 [6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide] 
• 178876-82-9 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester 
• 875051-80-2 6-amino-5-bromo-N-methyl-pyridine-2-carboxamide 
• 1221629-04-4 6-amino-5-bromopyridine 2-carboxylic acid 

Relevant articles and documents

Preparation process of 2-amino-3-bromo-6-methylpyridine

The invention discloses a preparation process of 2-amino-3-bromo-6-methylpyridine. The preparation process comprises the following steps: adding 2-amino-6-methylpyridine into a solvent, adding hydrogen peroxide in the presence of sulfuric acid, uniformly carrying out stirring, then adding bromine, and carrying out stirring for a reaction to obtain an intermediate 2-amino-3,5-dibromo-6-methylpyridine; and adding the 2-amino-3,5-dibromo-6-methylpyridine into a solvent, carrying out stirring, adding a lithiation reagent, and carrying out a reaction to obtain 2-amino-3-bromo-6-methylpyridine. Theinvention provides a preparation process of 2-amino-3-bromo-6-methylpyridine, the 2-amino-3-bromo-6-methylpyridine is prepared through a two-step reaction, and the preparation method is simple. Through addition of the hydrogen peroxide, the utilization rate of the bromine is increased from 50% to close to 100%, so that the usage amount of the bromine is greatly reduced, the yield of the product isincreased, emission of three wastes (waste gas, waste water, and industrial residues) is reduced, environment friendliness is achieved, and cost is saved.

Pyridyl imidazole derivatives and processes for the preparation thereof

Novel pyridyl imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: STR1 wherein: A is a straight, branched or cyclic C1 -C6 alkyl or alkenyl group, OR1 (wherein R1 is a hydrogen, or a straight, branched or cyclic C1 -C6 alkyl or alkenyl radical), or NR2 R3 (wherein R2 and R3 are independently a hydrogen, or a straight, branched or cyclic C1 -C6 alkyl radical); B is a group of the following formula STR2 D is a hydrogen; a halogen; a straight, branched or cyclic C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl group which is optionally substituted with OH, a C1 -C4 alkoxy radical, CO2 R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; tetrazol-5-yl; a perfluoro-C1 -C4 alkyl group; or N(R1)2, OR1, CO2 R1 or CON(R1)2, wherein R1 is the same as defined above; E is a hydrogen; a halogen; a straight or branched C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl group which is optionally substituted with OH, a C1 -C4 alkoxy radical, CO2 R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; a perfluoro-C1 -C4 alkyl group; NO2 ; or N(R1)2 or OR1, wherein R1 is the same as defined above; and n is 0 or an integer of 1 to 4.

Bromination of Pyridines. II. Bromination of Aminopicolines

The bromination of all ten possible aminopicolines 1-10 was investigated.In general, the major brominated product was that corresponding to electrophilic attack at the sites para or ortho to the amino group.