106148-27-0

Basic information

• Product Name: 4-benzyl-1-(2-phenylethyl)piperazine-2,6-dione
• Synonyms: 2,6-piperazinedione, 1-(2-phenylethyl)-4-(phenylmethyl)-; 4-Benzyl-1-(2-phenylethyl)piperazine-2,6-dione; 4-Benzyl-1-phenethyl-piperazine-2,6-dione
• CAS NO: 106148-27-0
• Molecular Formula: C₁₉H₂₀N₂O₂
• Molecular Weight: 308.3743
• EINECS: 600-719-5
• Mol File: 106148-27-0.mol

Chemical Properties

• Boiling Point: 493.2°C at 760 mmHg
• Flash Point: 220.8°C
• Density: 1.194g/cm³
• Vapor Pressure: 7.21E-10mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 4-benzyl-1-(2-phenylethyl)piperazine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-1-(2-phenylethyl)piperazine-2,6-dione(106148-27-0)
• EPA Substance Registry System: 4-benzyl-1-(2-phenylethyl)piperazine-2,6-dione(106148-27-0)

Safety Data

• Hazardous Substances Data: 106148-27-0(Hazardous Substances Data)

Upstream product

• 3987-53-9 N-benzyliminodiacetic acid 
• 64-04-0 phenethylamine 
• 67305-69-5 N-benzyliminodiacetic anhydride acid 

Downstream Products

• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 
• 61196-37-0 2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 
• 105279-85-4 2-benzyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one 
• 106148-28-1 4-benzyl-6-hydroxy-1-phenethylpiperazin-2-one 

Relevant articles and documents

Br?nsted acid-mediated cyclization-dehydrosulfonylation/reduction sequences: An easy access to pyrazinoisoquinolines and pyridopyrazines

An efficient and alternative synthetic approach has been developed to prepare various N-(arylethyl)piperazine-2,6-diones from 4-benzenesulfonyliminodiacetic acid and primary amines using carbonyldiimidazole in the presence of a catalytic amount of DMAP at ambient temperature. Piperazine-2,6-diones are successfully transformed to pharmaceutically useful pyridopyrazines or pyrazinoisoquinolines and ene-diamides via an imide carbonyl group activation strategy using a Br?nsted acid. Subsequent dehydrosulfonylation reactions of the ene-diamides, in a one pot manner, smoothly transformed them to substituted pyrazinones. A concise synthesis of praziquantel (1) has also been achieved through this method.

4-BENZYL-1-PHENETHYL-PIPERAZINE-2,6-DIONE PREPARATION METHOD, AND INTERMEDIATE AND PREPARATION METHOD THEREOF

The present invention provides a key new intermediate (a compound of formula III) of 4-benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound), a pharmaceutically acceptable salt thereof and a preparation method thereof. The present invention additi

4-BENZYL-1-PHENETHYL-PIPERAZINE-2,6-DIONE PREPARATION METHOD, AND INTERMEDIATE AND PREPARATION METHOD THEREOF

The present invention provides a key new intermediate (a compound of formula III) of 4-benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound), a pharmaceutically acceptable salt thereof and a preparation method thereof. The present invention additi

Synthesis and Anthelmintic Activity of a Series of Pyrazinobenzazepine Derivatives

A series of 1,2,3,4,6,7,8,12b-octahydropyrazinobenzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen.Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazinobenzazepine, epsiprantel (BAN) (22), was selected for further development.The structure-activity relationships are discussed.