- RADICAL ANIONS OF NITROSOIMIDAZOLES: PUTATIVE INTERMEDIATES IN THE MECHANISM OF ACTION OF NITROIMIDAZOLE ANTIBIOTICS
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The radical anions of 1-methyl-4-phenyl-5-nitrosoimidazole and 5-phenyl-4-nitrosoimidazole have been detected using temperature resolved e.s.r spectroscopic techniques and are proposed as putative intermediates in the oxidation of thiols to disulphides by the nitrosoimidazoles.
- Symons, Martyn C. R.,Bowman, W. Russell,Taylor, Peter F.
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- Antitumor Imidazotetrazines. 14. Synthesis and Antitumor Activity of 6- and 8-Ssubstituted Imidazo-1,2,3,5-tetrazinones and 8-Substituted Pyrazolo-1,2,3,5-tetrazinones
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The systematic variation of the potent antitumor agent mitozolomide (1) is extended to cover alteration of substituents at position 6 and 8 and to change the imidazo-1,2,3,5-tetrazinone (6) skeleton to the isomeric pyrazolo-1,2,3,5-tetrazino
- Lunt, Edward,Newton, Christopher G.,Smith, Christopher,Stevens, Graham P.,Stevens, Malcolm F. G.,et al.
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p. 357 - 366
(2007/10/02)
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