1062541-78-9

Basic information

• Product Name: 6-BroMo-2,4-diMethyl-3-pyridinol
• Synonyms: 6-BroMo-2,4-diMethyl-3-pyridinol;6-BroMo-2,4-diMethylpyridin-3-ol;6-bromo-2,4-dimethyl-3-hydroxypyridine
• CAS NO: 1062541-78-9
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.04852
• Mol File: 1062541-78-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BroMo-2,4-diMethyl-3-pyridinol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMo-2,4-diMethyl-3-pyridinol(1062541-78-9)
• EPA Substance Registry System: 6-BroMo-2,4-diMethyl-3-pyridinol(1062541-78-9)

Safety Data

• Hazardous Substances Data: 1062541-78-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-bromo-2,4-dimethyl-3-pyridinol is utilized as a pharmaceutical intermediate, playing a crucial role in the synthesis of a range of medications. Its chemical structure makes it a valuable component in the development of new therapeutic agents.
Used in Organic Synthesis:
In the realm of organic synthesis, 6-bromo-2,4-dimethyl-3-pyridinol serves as a building block, contributing to the creation of complex organic molecules. Its reactivity and structural features facilitate the formation of diverse chemical entities.
Used as an Antifungal Agent:
6-bromo-2,4-dimethyl-3-pyridinol is recognized for its antifungal properties, making it a potential candidate for use in applications where control of fungal growth is necessary, such as in medical or environmental settings.
Used as a Reagent in Chemical Reactions:
6-bromo-2,4-dimethyl-3-pyridinol also functions as a reagent in various chemical reactions, enabling specific transformations that are essential in the synthesis of target molecules.
Used in Agricultural Industry:
6-bromo-2,4-dimethyl-3-pyridinol has potential applications in agriculture, where it could be employed as a pesticide or herbicide. Its ability to control or eliminate unwanted organisms could contribute to more effective crop management strategies.

Upstream product

• 27296-76-0 2,4-dimethyl-pyridin-3-ol 
• 1062541-77-8 2-bromo-5-methoxy-4,6-dimethylpyridine 

Relevant articles and documents

NEW COMPOUNDS 578

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

NEW COMPOUNDS 574

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome,

Catalytic chain-breaking pyridinol antioxidants

(Chemical Equation Presented) The synthesis of 3-pyridinols carrying alkyltelluro, alkylseleno, and alkylthio groups is described together with a detailed kinetic, thermodynamic, and mechanistic study of their antioxidant activity. When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than α-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. In homogeneous phase, inhibition of styrene autoxidation absolute rate constants kinh for quenching of peroxyl radical were as large as 1 x 107 M-1 s -1, thus outperforming the best phenolic antioxidants including α-tocopherol. Tellurium-containing 3-pyridinols could be quantitatively regenerated in homogeneous phase by N-tert-butoxycarbonyl cysteine methyl ester, a lipid-soluble analogue of N-acetylcysteine. In the presence of an excess of the thiol, a catalytic mode of action was observed, similar to the one in the two-phase system. Overall, compounds bearing the alkyltelluro moiety ortho to the OH group were much more effective antioxidants than the corresponding para isomers. The origin of the high reactivity of these compounds was explored using pulse-radiolysis thermodynamic measurements, and a mechanism for their unusual antioxidant activity was proposed. The tellurium-containing 3-pyridinols were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agents, thereby acting as multifunctional (preventive and chain-breaking) catalytic antioxidants.

Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalisation of the metathesis products is possible both prior to and after aromatisation. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds.

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system. The Royal Society of Chemistry 2009.

COMPOUNDS COMPRISING A 3-PYRIDINOL OR 5-PYRIMIDINOL RING HAVING AN ORGANOSELENO OR ORGANOTELLURO SUBSTITUENT FOR USE AS ANTIOXIDANTS

Compounds comprising a 3-pyridinol or 5-pyrimidinol ring carrying an organoseleno- or organotelluro- substituent on the pyridine or pyrimidine ring, exhibit useful antioxidant properties. The compounds may for example be in accordance with the following formula (I) as defined herein. Catalytic chain-breaking and hydroperoxide decomposing antioxidant properties are also disclosed. Furthermore the compounds may be used in combination with a reducing agent. The compounds are useful for the stabilization of man-made and natural materials, or for the prevention or treatment of disorders caused by or involving free radical-mediated or oxidative tissue damage.

Catalytic chain-breaking pyridinol antioxidants

(Chemical Equation Presented) When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than α-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. The compounds were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agent.