27296-76-0

Basic information

• Product Name: 2,4-DIMETHYL-3-HYDROXYPYRIDINE
• Synonyms: 2,4-DIMETHYL-3-HYDROXYPYRIDINE;2,4-Dimethylpyridin-3-ol, 3-Hydroxy-2,4-lutidine;2,4-diMethyl-3-Pyridinol;2,4-Dimethyl-3-hydroxypyridine97%
• CAS NO: 27296-76-0
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• Product Categories: Pyridines
• Mol File: 27296-76-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 37-40
• Boiling Point: 295.409 °C at 760 mmHg
• Flash Point: 132.459 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIMETHYL-3-HYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-3-HYDROXYPYRIDINE(27296-76-0)
• EPA Substance Registry System: 2,4-DIMETHYL-3-HYDROXYPYRIDINE(27296-76-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 27296-76-0(Hazardous Substances Data)

Usage

General Description

2,4-Dimethyl-3-hydroxypyridine, also known as 2,4-lutidine, is a chemical compound that belongs to the class of pyridine derivatives. It is a colorless to pale yellow liquid with a strong, pungent odor. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It also has applications in the production of rubber and plastics. 2,4-Dimethyl-3-hydroxypyridine is considered to be moderately toxic if ingested and can cause irritation to the skin and eyes upon contact. It is important to handle this chemical with caution and follow proper safety measures.

InChI:InChI=1/C7H9NO/c1-5-3-4-8-6(2)7(5)9/h3-4,9H,1-2H3

Upstream product

• 1073-21-8 3-amino-2,4-dimethylpyridine 
• 124-38-9 carbon dioxide 
• 1173164-95-8 2,4-dimethyl-1-tosyl-1,2-dihydropyridin-3(6H)-one 
• 108-47-4 2,4-lutidine 
• 1074-76-6 2,4-dimethyl-3-nitropyridine 
• 7664-93-9 sulfuric acid 

Downstream Products

• 143509-33-5 2,4-dimethyl-3-hydroxypyridine N-oxide 
• 1062541-78-9 6-bromo-2,4-dimethyl-3-pyridinol 

Relevant articles and documents

Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalisation of the metathesis products is possible both prior to and after aromatisation. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds.

Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis

(Chemical Equation Presented) New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/ deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An

Synthesis and Antitumor Activity of 3- and 5-Hydroxy-4-methylpyridibe-2-carboxaldehyde Thiosemicarbazones

To develop an α-(N)-heterocyclic carboxaldehyde thiosemicarbazone with clinical utility as an anticancer agent, two analogues, 3-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-HMP) and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (5-HMP), of 5-hydroxypyridine-2-carboxaldehyde thiosemicarbazone (5-HP) have been designed and synthesized by two different methods. 3-HMP and 5-HMP both showed better antitumor activity than their respective parent compounds, 3-hydroxypyridine-2-carboxaldehyde thiosemicarbazone and 5-HP, in mice bearing the L1210 leukemia.