1062608-42-7

Basic information

• Product Name: 5-Bromo-3-iodopyrazin-2-amine
• Synonyms: 5-Bromo-3-iodopyrazin-2-amine;2-amino-3-iodo-5-bromo-pyrazine
• CAS NO: 1062608-42-7
• Molecular Formula: C4H3BrIN3
• Molecular Weight: 299.89519
• Mol File: 1062608-42-7.mol

Chemical Properties

• Boiling Point: 353.7±42.0 °C(Predicted)
• Appearance: /
• Density: 2.576±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.84±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-3-iodopyrazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-iodopyrazin-2-amine(1062608-42-7)
• EPA Substance Registry System: 5-Bromo-3-iodopyrazin-2-amine(1062608-42-7)

Safety Data

• Hazardous Substances Data: 1062608-42-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-Bromo-3-iodopyrazin-2-amine is used as a key intermediate in organic synthesis for the creation of complex organic compounds. Its unique structure and reactivity contribute to the formation of diverse chemical entities with potential applications across various fields.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 5-Bromo-3-iodopyrazin-2-amine serves as a building block for the development of pharmaceuticals and bioactive molecules. Its ability to modify the properties of these molecules enhances their therapeutic potential, making it an essential component in drug discovery and development processes.
Used in Drug Discovery and Development:
5-Bromo-3-iodopyrazin-2-amine is utilized as a valuable intermediate in drug discovery and development due to its capacity to alter the characteristics of bioactive molecules. This modification can lead to the enhancement of their efficacy, selectivity, and other pharmacological properties, which is crucial for the creation of novel therapeutic agents.
Used in Material Science:
Although not explicitly mentioned in the provided materials, the compound's unique structure and reactivity may also find applications in material science. Its potential uses could include the development of new materials with specific properties, such as those with altered electronic, optical, or mechanical characteristics.
Used in Chemical Engineering:
Similarly, the compound's properties might be harnessed in chemical engineering for various applications. This could involve the creation of new chemical processes or the improvement of existing ones, taking advantage of the compound's reactivity and structural features to achieve more efficient or effective outcomes.

Upstream product

• 59489-71-3 5-amino-2-bromopyrazine 

Downstream Products

• 625848-14-8 5-bromo-3-(4-(trifluoromethyl)phenyl)pyrazin-2-amine 

Relevant articles and documents

Synthesis method of heterocyclic substituted coelenterazine compound

The invention provides a compound, which is a compound as shown in a formula (I), or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as shown in the formula (I). The compound and 2-aminopyrazine can be subjected to one-step cyclization under an acidic condition, and various R-2-position heterocyclic ring or heteroaromatic ring substituted coelenterazine derivatives can be rapidly generated.

NEW ANTI-MALARIAL AGENTS

The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity

Replacement of the pyridine core of antimalarial 3,5-diaryl-2- aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other changes to the pyridine core and replacement or substitution of the 2-amino group led to loss of antimalarial activity. The 3,5-diaryl-2-aminopyrazine series showed impressive in vitro antiplasmodial activity against the K1 (multidrug resistant) and NF54 (sensitive) strains of Plasmodium falciparum in the nanomolar IC50 range of 6-94 nM while also demonstrating good in vitro metabolic stability in human liver microsomes. In the Plasmodium berghei mouse model, this series generally exhibited good efficacy at low oral doses. One of the frontrunner compounds, 4, displayed potent in vitro antiplasmodial activity with IC 50 values of 8.4 and 10 nM against the K1 and NF54 strains, respectively. When evaluated in P. berghei-infected mice, compound 4 was completely curative at an oral dose of 4 × 10 mg/kg.

ANTI -MALARIAL AGENTS

The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.