106469-51-6 Usage
Uses
Used in Pharmaceutical and Research Applications:
(+/-)PINDOBIND is utilized as a P1-purinergic receptor antagonist for its ability to block adenosine's effects at the P1 receptor. This action is crucial in the study and manipulation of physiological processes such as blood flow, neurotransmitter release, and cell proliferation.
Used in Asthma Treatment:
In the medical field, (+/-)PINDOBIND is used as a potential therapeutic agent for asthma, where its antagonistic properties can help in managing the condition by affecting the adenosine receptors involved in bronchoconstriction.
Used in Ischemia-Reperfusion Injury Management:
(+/-)PINDOBIND is applied as a protective agent in ischemia-reperfusion injury scenarios, leveraging its effects on adenosine receptors to mitigate the damage caused by the restoration of blood flow after a period of ischemia.
Used in Pain Management:
As a component in pain management therapies, (+/-)PINDOBIND is used to modulate the adenosine receptors that play a role in the perception of pain, offering a potential avenue for treating various types of pain.
Used in Neuroprotection and Neurodegenerative Disease Research:
(+/-)PINDOBIND is employed as a research tool in neuroprotection and the study of neurodegenerative diseases, given its potential implications in these areas. Its interaction with adenosine receptors could provide insights into the development of treatments for such conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 106469-51-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,4,6 and 9 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 106469-51:
(8*1)+(7*0)+(6*6)+(5*4)+(4*6)+(3*9)+(2*5)+(1*1)=126
126 % 10 = 6
So 106469-51-6 is a valid CAS Registry Number.
InChI:InChI=1/C23H34BrN3O3/c1-22(2,27-21(29)13-24)16-7-10-23(3,11-8-16)26-14-17(28)15-30-20-6-4-5-19-18(20)9-12-25-19/h4-6,9,12,16-17,25-26,28H,7-8,10-11,13-15H2,1-3H3,(H,27,29)
106469-51-6Relevant articles and documents
Affinity Labels for β-Adrenoreceptors: Preparation and Properties of Alkylating β-Blockers Derived from Indole
Pitha, Josef,Buchowiecki, Wieslaw,Milecki, Jan,Kusiak, John W.
, p. 612 - 615 (2007/10/02)
New alkylating ligands derived from indole with high affinity for β-adrenoceptors were synthesized and their properties examined.N8-(Bromoacetyl)-N1--(Z)-1,8-diamino-p-menthane (8) and its N1,N8 isomer (9) were prepared by the reaction of bromoacetyl bromide with a product of the condensation of 4-indolyl glycidyl ether with (Z)-1,8-diamino-p-menthane.A similar reaction employing 2-cyano-4-indolyl glycidyl ether yielded the respective cyano derivatives 10 and 11.Apparent affinities (Ki, M) for β-adrenoreceptors on membrane preparations from rat heart and lung were 4.6*10-10 and 1.34*10-9 for 8, 2.3*10-8 and 4.5*10-9 for 9, 6.1*10-10 and 1.49*10-9 for 10, and 1.83*10-9 and 2.78*10-9 for 11, respectively.When membranes were preincubated with the above ligands (1*10-8 M, 30 min, 30 deg C) and then washed extensively, reduction in the concentration of specific binding sites of dihydroalprenolol ranged from 7percent to 76percent and there was no change in KD of the remaining binding sites. (+/-)-Alprenolol and (-)-isoproterenol, but not (+)-isoproterenol, when included with the alkylating ligands in the preincubation mixtures, prevented the reduction in concentration of dihydroalprenolol binding sites.Compounds 8-11 alone did not stimulate adenylate cyclase activity in rat heart homogenates.However, these compounds inhibited (-)-isoproterenol-stimulated adenylate cyclase activity with Ki values ranging between 5*10-9 and 60*10-9 M.These results suggest that high-affinity irreversible β-adrenergic antagonists were obtained that may be useful for in vivo studies of β-adrenoceptors.
