106686-66-2Relevant articles and documents
Convenient one-pot synthesis of 8-substituted xanthines from 6-amino-5- nitrosouracils
Moore,Schow,Lum,Nelson,Melville
, p. 1123 - 1126 (2007/10/03)
C-8 substituted 1,3-dipropylxanthines are typically prepared by reduction of the aminonitrosouracil 2 to the corresponding diamine, which is acylated and then treated with strongly basic or dehydrating reagents to afford the xanthine 1. Working to discover a milder, more efficient, reaction sequence it was found that the C-6 amino group of 2 can be acylated, and that treatment of the resulting compounds with Sn(OAc)2 gave 8-substituted xanthines. Overall, a one-pot conversion of the aminonitrosouracil 2 to dipropylxanthines 1a-i was achieved involving in situ acylation, reduction, and cyclodehydration. These conditions can be used to generate the imidazole substructure in the presence of acid and base sensitive groups on the C-8 position that may be problematic the conventional three-step xanthine syntheses.
Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation
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, (2008/06/13)
A method of treating skin or hair for promoting pigmentation wherein a xanthine component, in an amount effective to promote pigmentation, is incorporated in liposomes or hydrated lipidic lamellar phases.
1,3,8-Trisubstituted xanthines. Effect of substitution pattern upon adenosine receptor A1/A2 affinity
Erickson, Ronald H.,Hiner, Roger N.,Feeney, Scott W.,Blake, Paul R.,Rzeszotarski, Waclaw J.,et al.
, p. 1431 - 1435 (2007/10/02)
A series of 11,8-substituted xanthines having three different substitution patterns on the 1- and 3-positions was prepared.These compounds were assessed for
