81250-33-1

Basic information

• Product Name: 6-Amino-1,3-dipropyl-5-nitrosouracil
• Synonyms: 6-AMino-5-nitroso-1,3-dipropyl-2,4(1H,3H)-pyriMidinedione;6-AMino-5-nitroso-1,3-dipropyluracil;6-amino-5-nitroso-1,3-dipropylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 81250-33-1
• Molecular Formula: C₁₀H₁₆N₄O₃
• Molecular Weight: 240.259
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates;Nucleotides;Amines
• Mol File: 81250-33-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 205-210°C
• Boiling Point: 309.4 °C at 760 mmHg
• Flash Point: 140.9 °C
• Appearance: Purple Solid
• Density: 1.34 g/cm³
• Storage Temp.: Refrigerator
• Stability: Stable at RT
• CAS DataBase Reference: 6-Amino-1,3-dipropyl-5-nitrosouracil(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-1,3-dipropyl-5-nitrosouracil(81250-33-1)
• EPA Substance Registry System: 6-Amino-1,3-dipropyl-5-nitrosouracil(81250-33-1)

Safety Data

• Hazardous Substances Data: 81250-33-1(Hazardous Substances Data)

Usage

Chemical Properties

6-Amino-1,3-dipropyl-5-nitrosouracil is Purple Solid

Uses

6-Amino-1,3-dipropyl-5-nitrosouracil is an intermediate used for the sythesis of xanthine derivatives

InChI:InChI=1S/C10H16N4O3/c1-3-5-13-8(11)7(12-17)9(15)14(6-4-2)10(13)16/h3-6,11H2,1-2H3

Upstream product

• 41862-14-0 6-amino-1,3-dipropyluracil 
• 859732-95-9 2-cyano-N-propyl-N-(propylcarbamoyl)acetamide 
• 623-95-0 1,3-dipropylurea 

Downstream Products

• 340021-17-2 3-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)propanoic acid 
• 137685-69-9 3,7-dihydro-8-[(+/-)-phenylpropyl]-1,3-dipropyl-1H-purine-2,6-dione 
• 116545-90-5 1,3-dipropyl-8-(4-cyanophenyl)xanthine 
• 94781-76-7 8-(4-hydroxyphenyl)-1,3-dipropyl-1,3,7-trihydropurine-2,6-dione 
• 132940-42-2 (E)-1,3-dipropyl-8-styrylxanthine 
• 85872-53-3 1,3-dipropyl-8-phenylxanthine 
• 132940-39-7 8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione 
• 132940-71-7 (E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-phenyl-acrylamide 
• 132940-49-9 4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-benzonitrile 
• 127252-60-2 6-Amino-5-{[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dipropyl-1H-pyrimidine-2,4-dione 
• 132940-68-2 N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-phenyl-propionamide 
• 127252-57-7 6-Amino-5-{[1-phenyl-meth-(E)-ylidene]-amino}-1,3-dipropyl-1H-pyrimidine-2,4-dione 
• 94781-77-8 6-amino-5-<(p-carboxybenzylidene)amino>-1,3-dipropyluracil 
• 94781-79-0 1,3-dipropyl-6-amino-5-(p-sulfobenzamido)uracil 

Relevant articles and documents

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1Receptor in Living Cells

The adenosine A1 receptor (A1AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including congestive heart failure, tachycardia, and neuropathic pain. The development of A1AR-selective fluorescent ligands will enhance our understanding of the subcellular mechanisms underlying A1AR pharmacology facilitating the development of more efficacious and selective therapies. Herein, we report the design, synthesis, and application of a novel series of A1AR-selective fluorescent probes based on 8-functionalized bicyclo[2.2.2]octylxanthine and 3-functionalized 8-(adamant-1-yl) xanthine scaffolds. These fluorescent conjugates allowed quantification of kinetic and equilibrium ligand binding parameters using NanoBRET and visualization of specific receptor distribution patterns in living cells by confocal imaging and total internal reflection fluorescence (TIRF) microscopy. As such, the novel A1AR-selective fluorescent antagonists described herein can be applied in conjunction with a series of fluorescence-based techniques to foster understanding of A1AR molecular pharmacology and signaling in living cells.

Synthesis of novel 3,7-dihydro-purine-2,6-Dione derivatives

Forty-six novel 3,7-dihydro-purine-2,6-dione derivatives (substituted xanthines) with great structural diversity were synthesized for biological activity screening. Three series of substituted xanthine analogs have been prepared in moderate to excellent y

Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6- methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as adenosine receptor antagonists

A new series of potential adenosine receptor antagonists with a [1,2,4]-triazolo-[3,4-f]-purine structure bearing at the 1 and 3 position n-propyl groups have been synthesized, and their affinities at the four human adenosine receptor subtypes (A1/s