106748-23-6

Basic information

• Product Name: 4-IODOTHIOBENZAMIDE
• Synonyms: 4-IODOTHIOBENZAMIDE
• CAS NO: 106748-23-6
• Molecular Formula: C₇H₆INS
• Molecular Weight: 263.09871
• Mol File: 106748-23-6.mol

Chemical Properties

• Melting Point: 164～165℃ (dec)
• Appearance: /
• CAS DataBase Reference: 4-IODOTHIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOTHIOBENZAMIDE(106748-23-6)
• EPA Substance Registry System: 4-IODOTHIOBENZAMIDE(106748-23-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 106748-23-6(Hazardous Substances Data)

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 3058-39-7 4-iodobenzonitrile 
• 3956-07-8 4-iodobenzamide 

Downstream Products

• 1313711-66-8 methyl 2-(4-iodophenyl)-4-methylthiazole-5-carboxylate 
• 1356114-95-8 3,5-bis(4-iodophenyl)-1,2,4-thiadiazole 
• 1537168-69-6 1-[2-(4-iodophenyl)-4-methylthiazol-5-yl]ethanone 
• 1537168-41-4 2-{1-[2-(4-(1-cyclohexenyl)phenyl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide 
• 1537168-42-5 2-{1-[2-(4-cyclohexylphenyl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide 
• 1537168-71-0 1-{2-[4-(1-cyclohexenyl)phenyl]-4-methylthiazol-5-yl}ethanone 
• 1537168-73-2 1-[2-(4-cyclohexylphenyl)-4-methylthiazol-5-yl]ethanone 
• 1589081-34-4 4-(chloromethyl)-2-(4-iodophenyl)thiazole 
• 1589081-19-5 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-iodophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile 
• 1607807-28-2 1-(2-(4'-hydroxy-[1,1'-biphenyl]-4-yl)-4-methylthiazol-5-yl)ethanone 
• 1607807-32-8 1-(2-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-methylthiazol-5-yl)ethanone 
• 1607807-34-0 1-(4-methyl-2-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thiazol-5-yl)ethanone 
• 1607807-30-6 1-(4-methyl-2-(4-(naphthalen-1-yl)phenyl)thiazol-5-yl)ethanone 
• 1607807-33-9 1-(4'-(5-acetyl-4-methylthiazol-2-yl)-[1,1'-biphenyl]-4-yl)ethanone 

Relevant articles and documents

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant burden both clinically and economically worldwide. Increasing resistance to current antibiotics requires an urgent investigation into novel classes of antimicrobial agents. This study presents a structure–activity relationship (SAR) rationale for pyrazole linked phenylthiazole analogues as new antibacterial agents. A library of 23 novel pyrazole linked phenylthiazole compounds were synthesised, followed by screening for antimicrobial activity against five bacterial species and two fungi. The most active compound 14b has shown promising antibacterial activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA, ATCC 43300) strain (MIC 4 μg/mL). Furthermore, the active pyrazole linked phenylthiazole compound exhibited a better toxicity profile than standard antibiotics. In summary, these results demonstrate that a pyrazole linked phenylthiazole scaffold has potential as a lead for further investigation to afford novel antibacterial agents.

A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature

A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed in this paper. In this reaction, readily available inorganic salt (Na2S·9H2O) serves as the sulfur source, and various functional groups of aryl nitriles were well tolerated at room temperature. In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide.

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.

Indole derivatives as inhibitors or factor Xa

The present invention relates to the inhibition of blood clotting proteins, and more particularly, to indole derivatives of formula (I), in which R1a, R1b, R1cR1d, R2, R3, R4and A are defined as indicated in the claims. The compounds of formula (I) are inhibitors of the blood clotting enzyme factor Xa. The invention also relates to processes for the preparation of the compounds of formula (I), to methods of inhibiting factor Xa activity and of inhibiting blood clotting, to use of the compounds of formula (I) in the treatment and prophylaxis of diseases which can be cured or prevented by the inhibition of factor Xa activity such as thromboembolic diseases, and to the use of the compounds of formula (I) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (I) in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (I) together with pharmaceutically acceptable carrier substances and/or auxiliary substances.