Titanocene(III)-catalyzed conversion of N-(epoxyalkyl)anilines into indolines
Densely substituted indolines and azaindolines can be obtained by the titanocene(III) chloride catalyzed reductive opening of N-(oxiran-2-ylmethyl) anilines. The reaction optimization, substrate scope, and limitations are discussed, and a mechanistic pathway for the epoxideopening rearrangement is proposed. ARKAT-USA, Inc.
MacIejewski, John P.,Wipf, Peter
experimental part
p. 92 - 119
(2011/06/20)
Titanocene(III)-catalyzed formation of indolines and azaindolines
(Chemical Equation Presented) Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.
Wipf, Peter,Maciejewski, John P.
supporting information; experimental part
p. 4383 - 4386
(2009/05/30)
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