- PIPERAZINYL OXOALKYL TETRAHYDRO-BETA-CARBOLINES AND RELATED ANALOGUES
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Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
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Page/Page column 66-67
(2009/03/07)
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- FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE
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Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
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Page/Page column 172-175
(2008/06/13)
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- Indole derivatives
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New indole derivatives of the general formula I STR1 in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br, W is H, OH, O-alkyl, NH2, NH-alkyl or N(alkyl)2, A is --(CH2)n --, --CH2 --S--CH2 CH2 --, --CH2 --SO--CH2 CH2 -- or --CH2 --SO2 --CH2 CH2 --, is --(CH2)m --, --CH=CH--, --CHOH--, --CO--, S, SO, SO2 or O, n is 2, 3, 4 or 5 and m is 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts, have effects on the central nervous system.
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