106792-40-9Relevant articles and documents
A strategy to avoid anomalous O-alkylation of 4-hydroxyindole by diethyl bromomalonate
Papageorgiou, George,Corrie, John E. T.
, p. 1101 - 1104 (2005)
Alkylation of 4-hydroxyindole with diethyl bromomalonate under standard conditions (potassium carbonate-acetone) gave the expected indolyloxymalonate ester 3 together with the anomalous indolyloxy-2-bromomalonate 4, Depending on conditions, the ratio of t
Synthesis and structure eassessment of psammopemmin a
Lebar, Matthew D.,Baker, Bill J.
, p. 862 - 866 (2010)
We have isolated meridianins A, B, C, and E from the Antarctic tunicate Synoicum sp. In the process of verifying the structure of these compounds it was noted that the physical data reported for meridianins bore a striking resemblance to that of psammopemmins. The psammopemmins are alkaloids bearing similar structures to the meridianins, but reported from the Antarctic sponge Psammopemma sp. To verify the structure originally proposed for psammopemmin A, the compound was synthesized. By comparing the 1H and 13C NMR data of reported and synthetic psammopemmin A with that of meridianin A, we infer that the correct structure of psammopemmin A isolated from Psammopemma sp. is actually that of meridianin A.
JAK INHIBITOR
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Page/Page column 88, (2009/10/21)
A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.
Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes
Lu, Biao,Falck, John R.
supporting information; experimental part, p. 7508 - 7510 (2009/03/12)
CSi investigation: The efficient iridium-catalyzed C-H functionalization/ silylation of a wide variety of N-, S-, and O-heteroarenes, including N-unsubstituted indoles, is promoted by 2-norbornene and features a high level of regioselectivity (see scheme; Ts = p-toluenesulfonyl, cod = cyclooctadiene). (Chemical Equation Presented)
Anionically substituted 7-Nitroindoline derivatives and their uses
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Page/Page column 8; 12, (2010/11/25)
Anionically substituted 7-nitroindoline derivatives are disclosed and their uses as caged compounds from which effector species such as neurotransmitters and amino acids are releasable on irradiation with light.
INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE
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Page/Page column 81, (2010/02/11)
The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: -C(M=C(R3A)-N(R3)-, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting β3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.
Substituted tricyclics
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, (2008/06/13)
A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.
Substituted tricyclics useful in sPLA2 induced diseases
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, (2008/06/13)
A class of novel tricyclics is diclosed of the formula (I) : is phenyl or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position; one of B or D is nitrogen and the other is carbon; is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1 -, 2-, or 3position, or a 6-membered hetero-cyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2- or 3-position, and nitrogen at the 1 -, 2-, 3- or 4-position; is a double or single bond; together with the use of such compounds for inhibiting SPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
