1207869-20-2

Basic information

• Product Name: C₂₇H₂₇N₃O₃
• Synonyms: C₂₇H₂₇N₃O₃
• CAS NO: 1207869-20-2
• Molecular Weight: 441.53
• Mol File: 1207869-20-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₇N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₇N₃O₃(1207869-20-2)
• EPA Substance Registry System: C₂₇H₂₇N₃O₃(1207869-20-2)

Safety Data

• Hazardous Substances Data: 1207869-20-2(Hazardous Substances Data)

Upstream product

• 1207868-94-7 tert-butyl 4-hydroxy-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate 
• 1411975-46-6 (4-(tert-butyldimethylsilyloxy)-1H-indol-2-yl)(4-phenoxyphenyl)methanone 
• 67-36-7 4-phenoxy benzaldehyde 
• 106792-40-9 4-((tert-butyldimethylsilyl)oxy)-1H-indole 
• 110-89-4 piperidine 
• 1207869-12-2 tert-butyl 4-(2-chloroethoxy)-2-(4-phenoxybenzoyl)-1H-indole-1-carboxylate 

Relevant articles and documents

Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5- hydroxyindole as a novel CaMKII inhibitor

Based on 2-(4-phenoxybenzoyl)-5-hydroxyindole (2), a novel structural class of CaMKII inhibitors were synthesized and further optimized. The strong acidity of the hydroxyl group and the lipophilic group at the 4 and 6-positions were found to be necessary for strong CaMKII inhibition. Compound 25 was identified as a promising compound with 50-fold more potent inhibitory activity for CaMKII than 2. Compound 25 also showed high selectivity for CaMKII over off-target kinases.