106898-37-7

Basic information

• Product Name: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile
• Synonyms: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile
• CAS NO: 106898-37-7
• Molecular Formula: C₉H₇N₅
• Molecular Weight: 185.18538
• Mol File: 106898-37-7.mol

Chemical Properties

• Appearance: /
• Density: 1.37
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(106898-37-7)
• EPA Substance Registry System: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile(106898-37-7)

Safety Data

• Hazardous Substances Data: 106898-37-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile is used as a potential candidate for the development of new drugs due to its structural features and properties. It may be studied for its potential biological activities and medicinal properties, contributing to the discovery of novel therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile is used as a building block in organic synthesis. Its unique structure allows for the creation of new compounds with valuable properties, expanding the scope of chemical synthesis and material development.
Used in Agrochemical Development:
5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile may also be utilized in the development of new agrochemicals. Its potential biological activities could lead to the creation of innovative products for agricultural applications, enhancing crop protection and yield.
Overall, the diverse applications of 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile across various industries highlight its significance in research and development, with the potential to contribute to advancements in medicine, chemistry, and agriculture.

Upstream product

• 20815-52-5 4-hydrazinopyridine hydrochloride 
• 123-06-8 Ethoxymethylenemalononitrile 
• 27256-91-3 4-pyridylhydrazine 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS

The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds.

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1) determined this to be a tight binding region with little room for modification. As predicted from the model, a large variety of modifications could be incorporated into the hydrazone aryl ring. This work led to GSK-3 inhibitors in the low nano-molar range.