5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile
• CAS No.: 106898-37-7
• Molecular Formula: C₉H₇N₅
• Molecular Weight: 185.188
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00548290
• Wikidata: Q72441737
• Mol file: 106898-37-7.mol

Synonyms:5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile;106898-37-7;5-amino-1-pyridin-4-ylpyrazole-4-carbonitrile;5-Amino-1-pyridin-4-yl-1H-pyrazole-4-carbonitrile;SCHEMBL6071143;DTXSID00548290;YJQFNOQKDZGZAE-UHFFFAOYSA-N;AKOS008099815;CS-0216968;EN300-65093;Z276597748

Chemical Property of 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile

Chemical Property:

• PSA: 80.52000
• Density: 1.37
• LogP: 1.30238
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 185.07014524
• Heavy Atom Count: 14
• Complexity: 239

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1N2C(=C(C=N2)C#N)N

Technology Process of 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile

There total 2 articles about 5-amino-1-(pyridin-4-yl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-hydrazinopyridine hydrochloride (20815-52-5) + Ethoxymethylenemalononitrile (123-06-8) → 5-amino-1-pyridin-4-yl-1H-pyrazole-4-carbonitrile (106898-37-7)

Guidance literature:

With triethylamine; In ethanol; for 0.5h; Heating / reflux;

Reference yield:

4-pyridylhydrazine (27256-91-3) + Ethoxymethylenemalononitrile (123-06-8) → 5-amino-1-pyridin-4-yl-1H-pyrazole-4-carbonitrile (106898-37-7)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1016/j.bmcl.2004.02.036

Reference yield:

5-amino-1-pyridin-4-yl-1H-pyrazole-4-carbonitrile (106898-37-7) → 4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(pyridin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:

Multi-step reaction with 3 steps

1: 110 °C

2: trichlorophosphate / 130 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 120 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.02.050

upstream raw materials:

4-pyridylhydrazine

Ethoxymethylenemalononitrile

4-hydrazinopyridine hydrochloride