107124-27-6

Basic information

• Product Name: DIMETHYL 5-(3,4-DICHLOROPHENYL)-2,2-DIOXO-2,3-DIHYDRO-1H-2LAMBDA6-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE
• Synonyms: DIMETHYL 5-(3,4-DICHLOROPHENYL)-2,2-DIOXO-2,3-DIHYDRO-1H-2LAMBDA6-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE;6,7-dimethyl 5-(3,4-dichlorophenyl)-2,2-dioxo-1H,3H-2lambda6-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate
• CAS NO: 107124-27-6
• Molecular Formula: C₁₆H₁₃Cl₂NO₆S
• Molecular Weight: 418.25
• Mol File: 107124-27-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIMETHYL 5-(3,4-DICHLOROPHENYL)-2,2-DIOXO-2,3-DIHYDRO-1H-2LAMBDA6-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL 5-(3,4-DICHLOROPHENYL)-2,2-DIOXO-2,3-DIHYDRO-1H-2LAMBDA6-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE(107124-27-6)
• EPA Substance Registry System: DIMETHYL 5-(3,4-DICHLOROPHENYL)-2,2-DIOXO-2,3-DIHYDRO-1H-2LAMBDA6-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE(107124-27-6)

Safety Data

• Hazardous Substances Data: 107124-27-6(Hazardous Substances Data)

Upstream product

• 110271-25-5 dimethyl 5-(3,3-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate 
• 110271-24-4 N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid 

Downstream Products

• 107124-31-2 2,2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole 
• 107124-32-3 2,2-dioxo-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis  

Relevant articles and documents

Synthesis, Chemical Reactivity, and Antileukemic Activity of 5-Substituted 6,7-Bis(hydroxymethyl)pyrrolothiazole Biscarbamates and the Corresponding Sulfoxides and Sulfones

A series of bis(N-methylcarbamate) and bis derivatives of 5-substituted 6,7-bis(hydroxymethyl)pyrrolothiazoles was prepared.The compounds were tested for activity in vivo against P388 lymphocytic leukemia, and the chemical reactivities of the compounds were compared by using the model nucleophile 4-(4-nitrobenzyl)pyridine (NBP).The 5-(3,4-dichlorophenyl)-substituted biscarbamates 6b, 8b, and 12b were inactive and unreactive toward NBP.The 5-methyl-substituted bicarbamates 6a, 7a, 8a, 9a, 12a, and 13a were all active against murine P388 lymphocytic leukemia.The chemical reactivities of the active compounds depended on the oxidation state of the sulfur.The reactivity toward NBP followed the order S > SO >> SO2.The sulfones 12a and 13a are the most active compounds in this series, and their lack of reactivity toward NBP led to the suggestion that 12a and 13a are activated in vivo.