107124-32-3Relevant academic research and scientific papers
Synthesis, Chemical Reactivity, and Antileukemic Activity of 5-Substituted 6,7-Bis(hydroxymethyl)pyrrolothiazole Biscarbamates and the Corresponding Sulfoxides and Sulfones
Anderson, Wayne K.,Mach, Robert H.
, p. 2109 - 2115 (2007/10/02)
A series of bis(N-methylcarbamate) and bis derivatives of 5-substituted 6,7-bis(hydroxymethyl)pyrrolothiazoles was prepared.The compounds were tested for activity in vivo against P388 lymphocytic leukemia, and the chemical reactivities of the compounds were compared by using the model nucleophile 4-(4-nitrobenzyl)pyridine (NBP).The 5-(3,4-dichlorophenyl)-substituted biscarbamates 6b, 8b, and 12b were inactive and unreactive toward NBP.The 5-methyl-substituted bicarbamates 6a, 7a, 8a, 9a, 12a, and 13a were all active against murine P388 lymphocytic leukemia.The chemical reactivities of the active compounds depended on the oxidation state of the sulfur.The reactivity toward NBP followed the order S > SO >> SO2.The sulfones 12a and 13a are the most active compounds in this series, and their lack of reactivity toward NBP led to the suggestion that 12a and 13a are activated in vivo.
SELLECTIVE REDUCTION OF CARBOXYLIC ACID ESTERS IN THE PRESENCE OF A FIVE-MEMBERED CYCLIC SULFONE
Anderson, Wayne K.,Mach, Robert H.
, p. 911 - 916 (2007/10/02)
Carboxylic acid esters can be selectively reduced in the presence of five-membered cyclic sulfones using AlH3-ether in anhydrous THF at cold temperature.
