HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
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Paragraph 0361; 0362; 0400
(2015/02/18)
HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
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Page/Page column 64
(2013/07/31)
Rigid analogues of antimitotic indolobenzazepinones: New insights into tubulin binding via molecular modeling
Two rigid analogues of 5-ethylindolobenzazepinone 4, a potent cytotoxic agent and inhibitor of tubulin polymerization, were prepared. The first was the indane derivative 5, in which the ethyl group is attached to the benzo moiety. The second was the pyrro
Pons, Valerie,Beaumont, Stephane,Tran Huu Dau, Marie Elise,Iorga, Bogdan I.,Dodd, Robert H.
experimental part
p. 565 - 570
(2011/10/02)
Microwave-accelerated reductive amination between ketones and ammonium acetate
A new procedure for reductive amination between ketones and ammonium acetate has been developed to access a variety of primary amines. This protocol takes advantage of microwave heating to significantly accelerate the reaction and offers a convenient and effective method to access some interesting amines. This new procedure compares favorably to previously reported approaches in terms of practicality, efficiency, and functional group compatibility.
Dong, Li,Aleem, Saadat,Fink, Cynthia A.
experimental part
p. 5210 - 5212
(2010/11/05)
SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
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Page/Page column 23
(2008/12/04)
THERAPEUTIC FLUOROETHYLCYANO GUANIDINES
Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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Page/Page column 21
(2008/12/04)
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