- IMAGING AGENTS
-
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly after production, readily cross the blood-brain barrier, and may utilize a number of different radionuclides.
- -
-
Paragraph 0088
(2017/05/17)
-
- Heteronuclear NMR Spectroscopic Investigations of Gallium Complexes of Substituted Thiosemicarbazones Including X-Ray Crystal Structure, a New Halogen Exchange Strategy, and 18F Radiolabelling
-
Five thiosemicarbazone ligands have been synthesized, and their coordination chemistry with gallium was investigated. The reaction of these thiosemicarbazones with gallium chloride in alcohol solutions in the presence of a base yielded the corresponding p
- Venkatachalam,Pierens,Bernhardt, Paul V.,Stimson,Bhalla,Lambert,Reutens
-
p. 1033 - 1048
(2016/10/12)
-
- Unexpected Formation of Thioglycolurils Precursors
-
Unexpectedly, nitrosation of 5,7-dialkyl-3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazine-6-ones(thiones) with sodium nitrite in glacial AcOH led to 3,3′-bis(5,7-dialkyl-1-nitroso-6-oxo(thioxo)-1,4,4a,5,7,7a-hexahydroimidazo[4,5-e]-1,2,4-triazinyl)disulfides that decomposed spontaneously into 1,3-dialkyl-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones(thiones) in DMSO-d6 in the presence of water.
- Gazieva, Galina A.,Kravchenko, Angelina N.
-
p. 1858 - 1863
(2015/11/09)
-
- Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
-
Bis(thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic properties. However, their mechanism of action remains unclear. We examined the structure-activity relationships of twelve bis(thiosemicarbazones) to elucidate factors
- Stefani, Christian,Al-Eisawi, Zaynab,Jansson, Patric J.,Kalinowski, Danuta S.,Richardson, Des R.
-
-
- Unexpected formation of 4-alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1, 2,4-triazine-3(2H)-thiones from 1,3-dialkyl-4,5-bis-(4-alkylthiosemicarbazido) imidazolidin-2-ones in acidic medium
-
4-Alkyl-5-(4-alkylthiosemicarbazido)-4,5-dihydro-1,2,4-triazine-3(2H) -thiones are obtained either by heating 1,3-dialkyl-4,5-bis-(4- alkylthiosemicarbazido)imidazolidin-2-ones in acidic medium or the reaction of 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-on
- Gazieva, Galina A.,Poluboyarov, Pavel A.,Kolotyrkina, Natal'ya G.,Lubuzh, Elena D.,Kravchenko, Angelina N.
-
-