The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory action on PAI-1 activity and being efficacious in the prevention and treatment of various diseases whose onset is associated with PAI-1 activity.
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Page/Page column 69
(2012/02/03)
Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes
A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.
Guo, Xiangyu,Li, Chao-Jun
supporting information; experimental part
p. 4977 - 4979
(2011/11/12)
SYNTHESIS OF POLYCARBOXYLIC ACIDS OF BIPHENYL. II. OXIDATION OF CYCLOHEXYLTOLUENES AND METHYLBIPHENYLS TO CARBOXYLIC ACIDS
During the liquid-phase catalytic oxidation of cyclohexyltoluenes and methylbiphenyls in the presence of a cobalt catalyst the methyl group exhibits high reactivity, and it increases in the series of ortho, meta, and para isomers. The minimal reactivity of the methyl group at the ortho position is explained by steric factors.
Koshel', S. G.,Shutova, I. V.,Shapiro, Yu. E.,Obukhova, T. A.,Rusakov, A. I.,Koshel', G. N.
p. 292 - 295
(2007/10/02)
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