107377-07-1

Basic information

• Product Name: 4-N-BUTYLBENZAMIDE
• Synonyms: 4-N-BUTYLBENZAMIDE;4-BUTYLBENZAMIDE;4-BUTYLAMINOMETHYL-PHENYLAMINE
• CAS NO: 107377-07-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 107377-07-1.mol

Chemical Properties

• Melting Point: 127 °C
• Boiling Point: 309.9 °C at 760 mmHg
• Flash Point: 141.2 °C
• Appearance: /
• Density: 1.018 g/cm³
• Vapor Pressure: 0.000622mmHg at 25°C
• Refractive Index: 1.533
• PKA: 16.20±0.50(Predicted)
• CAS DataBase Reference: 4-N-BUTYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-BUTYLBENZAMIDE(107377-07-1)
• EPA Substance Registry System: 4-N-BUTYLBENZAMIDE(107377-07-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 107377-07-1(Hazardous Substances Data)

Usage

Uses

Used in Research and Industrial Applications:
4-N-BUTYLBENZAMIDE is used as a building block for the synthesis of other organic compounds, serving as a key intermediate in the creation of various chemical entities. Its structural features make it a versatile component in the development of new molecules with specific functions and properties.
Used in Pharmaceutical Research:
4-N-BUTYLBENZAMIDE is used as a compound of interest in pharmaceutical research due to its potential to interact with receptors in the central nervous system. This interaction suggests that it may have applications in the development of drugs targeting neurological conditions or disorders.
Used in Organic Synthesis Methods:
The production of 4-N-BUTYLBENZAMIDE typically involves organic synthesis methods, which are crucial for obtaining this compound in a pure and stable form. These methods are essential for both research purposes and for scaling up to industrial levels of production.

InChI:InChI=1/C11H15NO/c1-2-3-4-9-5-7-10(8-6-9)11(12)13/h5-8H,2-4H2,1H3,(H2,12,13)

Upstream product

• 28788-62-7 4-butylbenzoyl chloride 
• 20651-71-2 4-butyl benzoic acid 
• 1336-21-6 ammonium hydroxide 
• 37920-25-5 1-(4-butylphenyl)ethanone 
• 15226-74-1 dicobalt octacarbonyl 
• 41492-05-1 p-bromobutylbenzene 
• 79887-09-5 (4-butylphenyl)acetylene 

Downstream Products

• 57802-79-6 4-n-butylbenzylamine 
• 60834-63-1 p-butylbenzyl alcohol 
• 1313711-82-8 2-(1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarboximidamide 
• 1313711-81-7 1-(2-(4-butylphenyl)-4-methylthiazol-5-yl)ethanone 
• 1208077-46-6 4-n-butylthiobenzamide 
• 113932-84-6 methyl (4-butylphenyl)carbamate 

Relevant articles and documents

Copper-catalyzed aerobic oxidative C-C bond cleavage for C-N bond formation: From ketones to amides

A novel copper-catalyzed aerobic oxidative C(CO)-C(alkyl) bond cleavage reaction of aryl alkyl ketones for C-N bond formation is described. A series of acetophenone derivatives as well as more challenging aryl ketones with long-chain alkyl substituents could be selectively cleaved and converted into the corresponding amides, which are frequently found in biologically active compounds and pharmaceuticals.

Method for preparing derivatives of benzamide under microwave condition in aqueous phase

The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.

Visible Light-Induced Iodine-Catalyzed Transformation of Terminal Alkynes to Primary Amides via C≡C Bond Cleavage under Aqueous Conditions

The visible light-induced iodine-catalyzed oxidative cleavage of the C≡C bond for transforming terminal alkynes into primary amides in the presence of ammonia under aqueous conditions is described. This metal-free protocol which ensued via initial hydroamination of the acetylene bond followed by liberation of diiodomethane (CH2I2) was found to be applicable to aromatic, heteroaromatic and aliphatic alkynes.

Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.

ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.

Antiatherosclerotic ureas and thioureas

This invention is concerned with ureas and thioureas which may be represented by the formula: STR1 wherein X represents at least one substituent selected from the group consisting of (C1 -C4)alkyl, (C1 -C4)alken