Samarium Barbier reactions of α-iodomethyloxazoles and thiazoles with aliphatic aldehydes
(Chemical Equation Presented) The reductive coupling of substituted α-iodomethyloxazoles and thiazoles with aliphatic aldehydes under Barbier conditions provides an effective method for the direct incorporation of intact heterocyclic systems.
Williams, David R.,Berliner, Martin A.,Stroup, Bryan W.,Nag, Partha P.,Clark, Michael P.
p. 4099 - 4102
(2007/10/03)
Samarium diiodide mediated barbier-type reaction of 2-chloromethylbenzoxazole and 2-chloromethylbenzothiazole with carbonyl compounds: A convenient synthesis of 1-(β-hydroxyalkyl)benzoxazoles and 1-(β-hydroxyalkyl)benzothiazoles
1-(β-Hydroxyalkyl)benzoxazoles and 1-(β -hydroxyalkyl)benzothiazoles were prepared via reductive addition reactions of 2-chloromethylbenzoxazole and 2-chloromethylbenzothiazole with carbonyl compounds under mild conditions mediated by SmI2.
Xu, Xiaoliang,Zhang, Yongmin
p. 3551 - 3559
(2007/10/03)
General Method for an Aldol-Type Reaction of 2-Methylbenzothiazole with Carbonyl Compounds
A general and versatile method for the preparation of a variety of β-hydroxybenzothiazoles (aldol-type adducts) by the reaction of α-lithio-2-methylbenzothiazole with carbonyl compounds was proposed.As an example of the use of α-lithio-2-methylbenzothiazo