107465-26-9Relevant articles and documents
Method for synthesizing [1,2,3]triazole[1,5-a]pyridines compound through non-catalyst N-N coupling reaction
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Paragraph 0032-0037; 0048-0052; 0060-0062, (2019/04/04)
The invention relates to a method for synthesizing [1,2,3]triazole[1,5-a]pyridines compound through non-catalyst N-N coupling reaction. The invention discloses an efficient method for synthesizing a product at one step without using a catalyst under a mild condition from a 2-pyridylamine compound and nitroso tert-butyl ester as a mild nitrogen atom source. The method is free from the catalyst, thereaction step is reduced, the condition is extremely mild, the efficiency is high, and the later modification can be performed on the biological active molecular, thereby facilitating the industrialproduction of [1,2,3]triazole[1,5-a]pyridines compound.
Triazolopyridines. Part 7. Preparation of Bromo-triazolopyridines and-triazoloisoquinolines
Abarca, Belen,Ballesteros, Rafael,Mojarred, Fatemeh,Jones, Gurnos,Mouat, Deborah J.
, p. 1865 - 1868 (2007/10/02)
Bromination of the 7-lithiotriazolopyridines (7) and (10) gave small yields of the 7-bromotriazolopyridines (8) and (11).Some ring opening was observed with the lithium derivative (7); ring opening was a major reaction when bromine reacted with 5-lithiotriazoloisoquinoline (15) or with the 7-trimethylsilyltriazolopyridine (20).Good yields of 7-bromotriazolopyridines (8) and (18) and of 5-bromotriazoloisoquinoline (19) were obtained from the appropriate lithio derivative and dibromotetrachloroethane.The properties of 5-trimethylsilyltriazoloisoquinoline and its lithium derivative are reported; protodesilylation has been achieved with compounds (25)-(28).
NUCLEOPHILIC SUBSTITUTIONS ON BROMOTRIAZOLOPYRIDINES - AN IMPROVED ROUTE TO 2,6-DISUBSTITUTED PYRIDINES AND TO 1,3-DISUBSTITUTED ISOQUINOLINES
Abarca, Belen,Ballesteros, Rafael,Jones, Gurnos,Mojarrad, Fatemeh
, p. 3543 - 3546 (2007/10/02)
A regiospecific synthesis of 2,6-disubstituted pyridines and of 1,3-disubstituted isoquinolines is described.