107640-56-2Relevant articles and documents
Synthesis of enantiopure fmoc-#-methylvaline
Shu, Lianhe,Wang, Ping
, p. 298 - 300 (2008)
An efficient synthesis of enantiopure Fmoc-α-methylvaline has been developed. The racemate was prepared in two steps from 3-methyl-2-butanone and was resolved using a chiral amine, (S)- 1,2,3,4-tetrahydro-1-naphthylamine to give the desired, enantiopure S
Synthesis of 4,4-Disubstituted 1,3-Thiazol-5(4H)-thiones
Jenny, Christjohannes,Heimgartner, Heinz
, p. 374 - 388 (2007/10/02)
An easy synthesis for the 1,3-thiazol-5(4H)-thiones 5, a class of heterocycles which have hitherto only been available with difficulty, is described.Reaction of 3-amino-2H-azirines 25 with thiocarboxylic acids at 0 deg yields monothiodiamides of type 20 (Scheme 6) which, on treatment with Lawesson reagent at 100 deg, undergo thiation and cyclization to give 5 in good yield.