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Benzoyl Chloride 98-88-4 99%
Cas No: 98-88-4
USD $ 2300.0-2300.0 / Metric Ton 1 Metric Ton 5000 Metric Ton/Year Wuhan Biet Co., Ltd Contact Supplier
Benzoyl chloride Manufacturer/High quality/Best price/In stock
Cas No: 98-88-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
high purity Benzoyl Chloride CAS:98-88-4
Cas No: 98-88-4
USD $ 1.9-2.5 / Kilogram 1 Kilogram 999999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Benzoyl Chloride? supplier in China
Cas No: 98-88-4
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Benzoyl chloride alpha-Chlorobenzaldehyde
Cas No: 98-88-4
USD $ 8.0-8.0 / Gram 1 Gram 100 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Good quality Benzoyl chloride//98-88-4
Cas No: 98-88-4
No Data 1 Metric Ton 2000 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
Benzoyl chloride CAS# 98-88-4 99%
Cas No: 98-88-4
No Data 1 Kilogram 500 Metric Ton/Year ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
Benzoyl chloride
Cas No: 98-88-4
No Data 1 Kilogram 20 Metric Ton/Week Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Benzoyl chloride
Cas No: 98-88-4
No Data 1 1 Ality Chemical Corporation Contact Supplier
Benzoyl chloride
Cas No: 98-88-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier

98-88-4 Usage

Physical and Chemical Properties

Its pure product is a colorless and transparent flammable liquid, which is smoking exposed to air in the air. In Industry, it is slightly pale yellow, with a strong pungent odor. Its steam has a strong stimulating effect for eye mucous membranes, skin and respiratory tract, by stimulating the mucous membranes and eyes tear. Benzoyl chloride Melting point is-1.0 ℃, boiling point is 197.2 ℃, and the relative density is 1.212 (20 ℃), while a flash point is 72 ℃, and refractive index (n20) is 1.554. It is soluble in the ether, chloroform, benzene and carbon disulfide. It can gradually decomposed in water or ethanol, ammonia, which generates benzoic acid, generating benzamide, ethyl benzoate and hydrogen chloride. In the laboratory, it can be obtained by distillation of benzoic acid and phosphorus pentachloride under anhydrous conditions. Industrial production process can be obtained by the use of thionyl chloride benzaldehyde. Benzoyl chloride is an important intermediate for preparing dyes, perfumes, organic peroxides, resins and drugs. It is also used in photography and artificial tannin production, which was formerly used as an irritant gas in chemical warfare.

Application

Benzoyl chloride is used for organic synthesis, dye and pharmaceutical raw material, manufacturing initiator benzoyl peroxide, t-butyl peroxybenzoate, pesticides and herbicides. In pesticides, it is a new insecticide, which is inducible isoxazole parathion (Isoxathion, Karphos) intermediate. Benzoyl chloride is an important benzoyl and benzyl reagent. Most of benzoyl chloride is used in the production of benzoyl peroxide, and secondly for the production of benzophenone, benzyl benzoate, benzyl cellulose. Benzoyl peroxide catalyzes polymerization initiator for the monomer plastic, polyester, epoxy, acrylic resin production, self-curing agent, which is a glass fiber material, fluorine rubber, silicone crosslinking agents, oil refined, bleached flour, fiber decolorizing.

Chemical Properties

Transparent, colorless liquid; pungent odor; vapor causes tears. Soluble in ether and carbon disulfide; decomposes in water. Combustible.

Chemical Properties

Benzoyl chloride is a colorless to slight brown liquid with a strong, penetrating odor.

Uses

Benzoyl Chloride is used in the manufacturing of dye intermediates.

Uses

For acylation, i.e., introduction of the benzoyl group into alcohols, phenols, and amines (Schotten-Baumann reaction); in the manufacture of benzoyl peroxide and of dye intermediates. In organic analysis for making benzoyl derivatives for identification purposes.

Uses

Benzoyl chloride is widely utilized for the synthesis of peroxides. It is employed in the production of dyes and perfumes. It also serves in the manufacturing of pharmaceuticals and resins.

Definition

A liquid acyl chloride used as a benzoylating agent.

Production Methods

Benzoyl chloride can be prepared from benzoic acid by reaction with PCl5 or SOCl2, from benzaldehyde by treatment with POCl3 or SO2 Cl2, from benzotrichloride by partial hydrolysis in the presence of H2SO4 or FeCl3, from benzal chloride by treatment with oxygen in a radical source, and from several other miscellaneous reactions. Benzoyl chloride can be reduced to benzaldehyde, oxidized to benzoyl peroxide, chlorinated to chlorobenzoyl chloride and sulfonated to m-sulfobenzoic acid. It will undergo various reactions with organic reagents. For example, it will add across an unsaturated (alkene or alkyne) bond in the presence of a catalyst to give the phenylchloroketone:

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 702, 1951 DOI: 10.1021/ja01146a061Synthesis, p. 306, 1983 DOI: 10.1055/s-1983-30314

General Description

A colorless fuming liquid with a pungent odor. Flash point 162°F. Lachrymator, irritating to skin and eyes. Corrosive to metals and tissue. Density 10.2 lb / gal. Used in medicine and in the manufacture of other chemicals.

Reactivity Profile

Benzoyl chloride reacts violently with protic solvents such as alcohols, with amines and amides (for example dimethylformamide [Bretherick 1979 p. 6] ) and with inorganic bases. Causes the violent decomposition of dimethyl sulfoxide [Chem. Eng. News 35(9): 87 1957]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Friedel-Crafts acylation of naphthalene using Benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent [Clar, E. et al., Tetrahedron, 1974, 30, 3296].

Hazard

Highly toxic. Strong irritant to skin, eyes, and mucous membranes, and via ingestion, inhala- tion. Upper respiratory tract irritant. Probable car- cinogen.

Health Hazard

INHALATION: may irritate eyes, nose and throat. INGESTION: causes acute discomfort. SKIN: causes irritation and burning.

Chemical Reactivity

Reactivity with Water Slow reaction with water to produce hydrochloric acid fumes. The reaction is more rapid with steam; Reactivity with Common Materials: Slow corrosion of metals but no immediate danger; Stability During Transport: Not pertinent; Neutralizing Agents for Acids and Caustics: Soda ash and water, lime; Polymerization: Does not occur; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen withexperimental tumorigenic data by skin contact. Humansystemic effects by inhalation: unspecified effects onolfaction and respiratory systems. Corrosive effects on theskin, eyes, and mucous membranes by inhalation.Flammable whe

Potential Exposure

Benzoyl chloride is used as a chemical intermediate; in organic synthesis; to produce other chemicals, dyes, perfumes, herbicides, and medicines.

Shipping

UN 1736 Benzoylchloride, Hazard class: 8; Labels: 8—Corrosive material.

Purification Methods

A solution of benzoyl chloride (300mL) in *C6H6 (200mL) is washed with two 100mL portions of cold 5% NaHCO3 solution, separated, dried with CaCl2 and distilled [Oakwood & Weisgerber Org Synth III 113 1955]. Repeated fractional distillation at 4mm Hg through a glass helices-packed column (avoiding porous porcelain or silicon-carbide boiling chips, and hydrocarbon or silicon greases on the ground joints) gave benzoyl chloride that did not darken on addition of AlCl3. Further purification is achieved by adding 3 mole% each of AlCl3 and toluene, standing overnight, and distilling off the benzoyl chloride at 1-2mm [Brown & Jenzen J Am Chem Soc 80 2291 1958]. Refluxing for 2hours with an equal weight of thionyl chloride before distillation has also been used. [Beilstein 9 IV 721.] Strong IRRITANT. Use in a fume cupboard.

Incompatibilities

May form explosive mixture with air. Contact with heat, hot surfaces, and flames causes decomposition, forming phosgene and hydrogen chloride. Water contact may be violent; forms hydrochloric acid. Reactions with amines, alcohols, alkali metals, dimethyl sulfoxide, strong oxidizers, and metal salts may be violent, causing fire and explosions. Attacks metals in the presence of moisture, forming explosive hydrogen gas. Attacks some plastics, rubber or coatings.

Waste Disposal

Pour into sodium bicarbonate solution and flush to sewer.
InChI:InChI=1/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5H

98-88-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (B0105)  Benzoyl Chloride  >98.0%(GC)(T) 98-88-4 25mL 100.00CNY Detail
TCI America (B0105)  Benzoyl Chloride  >98.0%(GC)(T) 98-88-4 500mL 240.00CNY Detail
Alfa Aesar (A14107)  Benzoyl chloride, 99+%    98-88-4 250g 215.0CNY Detail
Alfa Aesar (A14107)  Benzoyl chloride, 99+%    98-88-4 1000g 368.0CNY Detail
Alfa Aesar (A14107)  Benzoyl chloride, 99+%    98-88-4 5000g 1633.0CNY Detail
Sigma-Aldrich (259950)  Benzoylchloride  ACS reagent, 99% 98-88-4 259950-5ML 391.95CNY Detail
Sigma-Aldrich (259950)  Benzoylchloride  ACS reagent, 99% 98-88-4 259950-100ML 522.99CNY Detail
Sigma-Aldrich (259950)  Benzoylchloride  ACS reagent, 99% 98-88-4 259950-250ML 985.14CNY Detail
Sigma-Aldrich (259950)  Benzoylchloride  ACS reagent, 99% 98-88-4 259950-1L 2,548.26CNY Detail
Sigma-Aldrich (320153)  Benzoylchloride  ReagentPlus®, 99% 98-88-4 320153-1L 966.42CNY Detail

98-88-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzoyl chloride

1.2 Other means of identification

Product number -
Other names Benzoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98-88-4 SDS

98-88-4Synthetic route

acetophenone
98-86-2

acetophenone

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
Stage #1: acetophenone With pyridine; disulfur dichloride In chlorobenzene at 20℃; for 3h;
Stage #2: With sulfuryl dichloride In chlorobenzene at 20 - 132℃; for 17.5h;
87%
Stage #1: acetophenone With pyridine; sulfur monochloride In chlorobenzene at 75℃; for 2.5h;
Stage #2: In chlorobenzene at 137℃; for 19h;
With pyridine; disulfur dichloride at 70 - 137℃; for 21.5h; Reagent/catalyst; Concentration;82 %Spectr.
benzoic acid tert-butyl ester
774-65-2

benzoic acid tert-butyl ester

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With phosphorus trichloride In acetonitrile at 80℃; for 3h; Solvent; Time; Schlenk technique;96%
With thionyl chloride; water at 23℃; for 5h; Sealed tube;
benzaldehyde
100-52-7

benzaldehyde

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere;100%
With iron(III) chloride; Benzotrichlorid In benzene at 60℃; Rate constant; Mechanism; Thermodynamic data; ΔH(activ.), ΔS(activ.), various temperature, various solvents, various concentration ratios;
With chlorine
Benzotrichlorid
98-07-7

Benzotrichlorid

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With FeCl389%
With lead(II) oxide
With zinc(II) oxide
benzoic acid
65-85-0

benzoic acid

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With 1,2,3-Benzotriazole; thionyl chloride In dichloromethane at 20℃; Substitution;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 35℃; for 1h;100%
benzyl alcohol
100-51-6

benzyl alcohol

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With chlorine at 130 - 150℃; anschliessendes Erhitzen auf 190-200grad;
With thionyl chloride In chloroform
With trichloroisocyanuric acid In dichloromethane at 20℃; for 120h; Inert atmosphere;
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere;
With trichloroisocyanuric acid In dichloromethane at 20℃; Inert atmosphere;
benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride at 160 - 180℃;
With chlorine
With thionyl chloride In chloroform; N,N-dimethyl-formamide Reflux;
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 60 °C / pH 3 / Schlenk technique; Inert atmosphere
2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 17 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
View Scheme
acifluorfen
50594-66-6

acifluorfen

A

benzoyl chloride
98-88-4

benzoyl chloride

B

5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoyl chloride
67446-83-7

5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoyl chloride

Conditions
ConditionsYield
With thionyl chloride In toluene
With thionyl chloride In toluene
With thionyl chloride In toluene
2,2'-dithiobenzoic acid
119-80-2

2,2'-dithiobenzoic acid

Benzotrichlorid
98-07-7

Benzotrichlorid

A

2,2'-dithiodibenzoic acid dichloride
19602-82-5

2,2'-dithiodibenzoic acid dichloride

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With iron(III) chloride In toluene at 100℃; Inert atmosphere;A 16.4 g
B 12.9 g
2,2'-dithiobenzoic acid
119-80-2

2,2'-dithiobenzoic acid

Benzotrichlorid
98-07-7

Benzotrichlorid

A

2-chlorosulfenylbenzoyl chloride
3950-02-5

2-chlorosulfenylbenzoyl chloride

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
Stage #1: 2,2'-dithiobenzoic acid; Benzotrichlorid With iron(III) chloride In chlorobenzene at 100℃; Inert atmosphere;
Stage #2: With chlorine at 60℃; for 1h; Inert atmosphere;
A 18.9 g
B 12.6 g
iodobenzene
591-50-4

iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0); benzyltriphenylphosphonium chloride In toluene at 110℃; under 38002.6 Torr; for 24h; Glovebox; Autoclave; Inert atmosphere;71%
oxalyl dichloride
79-37-8

oxalyl dichloride

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With benzoic acid In N-methyl-acetamide; dichloromethane; Propargylamine
With benzoic acid In N-methyl-acetamide; dichloromethane; Propargylamine
oxalyl dichloride
79-37-8

oxalyl dichloride

ethyl 2-chloro-6-methoxybenzoate
172217-12-8

ethyl 2-chloro-6-methoxybenzoate

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With sodium hydroxide; bromine; acetic acid In ethanol; dichloromethane; water
sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

benzyl alcohol
100-51-6

benzyl alcohol

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With thionyl chloride In tetrahydrofuran
5-carbethoxythiophene-2-carboxylic acid
156910-49-5

5-carbethoxythiophene-2-carboxylic acid

A

5-carbethoxythiophene-2-carbonyl chloride
156910-44-0

5-carbethoxythiophene-2-carbonyl chloride

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With (COCl)2 In dichloromethane; N,N-dimethyl-formamide
Benzotrichlorid
98-07-7

Benzotrichlorid

1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With iron(III) chloride In water
p-Tolylisocyanate
622-58-2

p-Tolylisocyanate

A

1-isocyanato-2-chlorosulfonyl-4-methyl benzene

1-isocyanato-2-chlorosulfonyl-4-methyl benzene

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With sulfur trioxide In Benzotrichlorid; 1,2-dichloro-ethane
1-chloro-4-methyl-2-nitro-benzene
89-60-1

1-chloro-4-methyl-2-nitro-benzene

A

4-methyl-2-nitrobenzoic acid
27329-27-7

4-methyl-2-nitrobenzoic acid

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
CuCN In aq H2 SO4; benzonitrile; N,N-dimethyl-formamide
2-(2-phthalimidoethoxy)-acetic acid
69676-65-9

2-(2-phthalimidoethoxy)-acetic acid

A

2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)acetyl chloride

2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)acetyl chloride

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With iron(III) chloride; Benzotrichlorid In toluene Temperature; Solvent; Reflux;
iodobenzene
591-50-4

iodobenzene

isopentanoyl chloride
108-12-3

isopentanoyl chloride

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;92 %Chromat.
iodobenzene
591-50-4

iodobenzene

Hexanoyl chloride
142-61-0

Hexanoyl chloride

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;89 %Chromat.
iodobenzene
591-50-4

iodobenzene

n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;81 %Chromat.
bromobenzene
108-86-1

bromobenzene

ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;7 %Chromat.
2-amino-4,6-difluoro-benzothiazole
119256-40-5

2-amino-4,6-difluoro-benzothiazole

A

N-(4.6-Difluoro-benzothiazol-2-yl)-benzamide

N-(4.6-Difluoro-benzothiazol-2-yl)-benzamide

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
A 82%
B n/a
disodium hydrogenphosphate

disodium hydrogenphosphate

3-(2', 3'-dibromopropionamido)benzoyl chloride

3-(2', 3'-dibromopropionamido)benzoyl chloride

2,3-dibromo-propionyl chloride
18791-02-1

2,3-dibromo-propionyl chloride

meta-aminobenzoic acid
99-05-8

meta-aminobenzoic acid

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With hydrogenchloride In water
dimethylsulfoxide (DMSO)

dimethylsulfoxide (DMSO)

1,2-dibromo-1,1,2,2-tetrafluoroethane
124-73-2

1,2-dibromo-1,1,2,2-tetrafluoroethane

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

A

methyl 4-(2-bromo-1,1,2,2-tetrafluoroethoxy)benzoate

methyl 4-(2-bromo-1,1,2,2-tetrafluoroethoxy)benzoate

B

benzoyl chloride
98-88-4

benzoyl chloride

Conditions
ConditionsYield
With potassium hydroxide In methanol
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