Cucurbituril-resisted acylation of the anti-tuberculosis drug isoniazid via a supramolecular strategy
A chemical investigation reveals that the resistance to acylation of an anti-tuberculosis drug, isoniazid is a consequent result of the inclusion or exclusion of cucurbit[n]urils (n = 6 or 7). The 1H NMR spectra analysis shows that the differen
Cong, Hang,Li, Chun-Rong,Xue, Sai-Feng,Tao, Zhu,Zhu, Qian-Jiang,Wei, Gang
Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity
The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs. Despite the various drugs currently under evaluation, ison
Pd-catalyzed oxidative annulation of hydrazides with isocyanides: Synthesis of 2-amino-1,3,4-oxadiazoles
An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4- oxadiazoles and their derivatives.
Fang, Tao,Tan, Qitao,Ding, Zhengwei,Liu, Bingxin,Xu, Bin
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p. 2342 - 2345
(2014/05/20)
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