1078-38-2

Basic information

• Product Name: (N)1-acetylisoniazid
• Synonyms: (N)1-acetylisoniazid;ACETYLISONIAZID;HYDRAZINE,1-ACETYL-2-ISONICOTINYL-;1-Acetyl-2-isonicotinoylhydrazine;Acetylisoniazide;N-Acetylisoniazid;NSC-36084;2-Acetylhydrazide-4-pyridinecarboxylic Acid
• CAS NO: 1078-38-2
• Molecular Formula: C8H9N3O2
• Molecular Weight: 179.17596
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 1078-38-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 158-159°C
• Boiling Point: 311.69°C (rough estimate)
• Flash Point: 231.1°C
• Appearance: /
• Density: 1.2896 (rough estimate)
• Vapor Pressure: 1.37E-08mmHg at 25°C
• Refractive Index: 1.7400 (estimate)
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (N)1-acetylisoniazid(CAS DataBase Reference)
• NIST Chemistry Reference: (N)1-acetylisoniazid(1078-38-2)
• EPA Substance Registry System: (N)1-acetylisoniazid(1078-38-2)

Safety Data

• Hazardous Substances Data: 1078-38-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

A metabolite of Isoniazid (I821450)

Definition

ChEBI: A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom.

InChI:InChI=1/C8H9N3O2/c1-6(12)10-11-8(13)7-2-4-9-5-3-7/h2-5H,1H3,(H,10,12)(H,11,13)

Upstream product

• 54-85-3 isoniazid 
• 108-24-7 acetic anhydride 
• 18725-37-6 (R)-2-acetylamino-3-(acetylthio)propionic acid 
• 15312-11-5 S-acetylcysteine 
• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 1068-57-1 acetic acid hydrazide 

Downstream Products

• 58022-65-4 2-methyl-5-(pyridin-4-yl)-1,3,4-oxadiazole 

Relevant articles and documents

Cucurbituril-resisted acylation of the anti-tuberculosis drug isoniazid via a supramolecular strategy

A chemical investigation reveals that the resistance to acylation of an anti-tuberculosis drug, isoniazid is a consequent result of the inclusion or exclusion of cucurbit[n]urils (n = 6 or 7). The 1H NMR spectra analysis shows that the differen

Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs. Despite the various drugs currently under evaluation, ison