1078-38-2

Usage

Uses

Used in Pharmaceutical Industry:
(N)1-acetylisoniazid is used as an active pharmaceutical ingredient for the treatment of tuberculosis. It is derived from Isoniazid, a first-line antitubercular drug, and plays a crucial role in the management of the disease by targeting and inhibiting the growth of Mycobacterium tuberculosis, the bacteria responsible for tuberculosis.
Used in Research and Development:
(N)1-acetylisoniazid is also utilized as a research compound in the field of medicinal chemistry. It serves as a valuable tool for understanding the mechanisms of action, resistance, and potential improvements in the treatment of tuberculosis. This knowledge can contribute to the development of new and more effective antitubercular drugs.
Used in Quality Control and Standardization:
In the pharmaceutical industry, (N)1-acetylisoniazid is employed as a reference compound for quality control and standardization purposes. It helps ensure the consistency, potency, and purity of Isoniazid-containing drug products, thereby maintaining the safety and efficacy of these medications for patients.

InChI:InChI=1/C8H9N3O2/c1-6(12)10-11-8(13)7-2-4-9-5-3-7/h2-5H,1H3,(H,10,12)(H,11,13)

Upstream product

• 54-85-3 isoniazid 
• 108-24-7 acetic anhydride 
• 18725-37-6 (R)-2-acetylamino-3-(acetylthio)propionic acid 
• 15312-11-5 S-acetylcysteine 
• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 1068-57-1 acetic acid hydrazide 

Downstream Products

• 58022-65-4 2-methyl-5-(pyridin-4-yl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Cucurbituril-resisted acylation of the anti-tuberculosis drug isoniazid via a supramolecular strategy

A chemical investigation reveals that the resistance to acylation of an anti-tuberculosis drug, isoniazid is a consequent result of the inclusion or exclusion of cucurbit[n]urils (n = 6 or 7). The 1H NMR spectra analysis shows that the differen

Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs. Despite the various drugs currently under evaluation, ison

Pd-catalyzed oxidative annulation of hydrazides with isocyanides: Synthesis of 2-amino-1,3,4-oxadiazoles

An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4- oxadiazoles and their derivatives.