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107842-58-0

5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile is an organic compound with the molecular formula C11H9N5O2. It is a derivative of pyrazole, a five-membered heterocyclic compound, and features an amino group, a methyl group, a nitrophenyl group, and a carbonitrile group. 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.

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  • 107842-58-0 Structure

  • Basic information

    1. Product Name: 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile
    2. Synonyms: 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile;5-Amino-4-cyano-3-methyl-1-(3-nitrophenyl)pyrazole
    3. CAS NO:107842-58-0
    4. Molecular Formula: C10H6N5O2R
    5. Molecular Weight: 228.19
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 107842-58-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile(107842-58-0)
    11. EPA Substance Registry System: 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile(107842-58-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 107842-58-0(Hazardous Substances Data)

107842-58-0 Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile is used as a reactant in the preparation of phenylpyrazole derivatives. These derivatives have shown potential as novel anti-HIV agents, making this compound a valuable starting material for the development of new medications to combat the human immunodeficiency virus (HIV).

Check Digit Verification of cas no

The CAS Registry Mumber 107842-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,8,4 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 107842-58:
(8*1)+(7*0)+(6*7)+(5*8)+(4*4)+(3*2)+(2*5)+(1*8)=130
130 % 10 = 0
So 107842-58-0 is a valid CAS Registry Number.

107842-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Amino-3-methyl-1-(3-nitrophenyl)-1H-pyrazole-4-carbonitrile

1.2 Other means of identification

Product number -
Other names 5-Amino-4-cyano-3-methyl-1-(3-nitrophenyl)pyrazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107842-58-0 SDS

107842-58-0Relevant articles and documents

The pyrazole derivative or its salt in a pharmaceutical composition containing them

-

Paragraph 0129; 0143, (2017/01/26)

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

Mizuhara, Tsukasa,Kato, Takayuki,Hirai, Atsushi,Kurihara, Hideki,Shimada, Yasuhiro,Taniguchi, Masahiko,Maeta, Hideki,Togami, Hiroaki,Shimura, Kazuya,Matsuoka, Masao,Okazaki, Shiho,Takeuchi, Tomoki,Ohno, Hiroaki,Oishi, Shinya,Fujii, Nobutaka

, p. 4557 - 4561 (2013/08/23)

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.

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