- 1,1-DICHLORO-2,2,2-TRIFLUOROETHYL ZINC AND LITHIUM COMPOUNDS IN ASYMMETRIC SYNTHESIS
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Addition of 1,1-dichloro-2,2,2-trifluoroethyl zinc chloride 2 complexed with optically pure ligands leads to zero percentage of asymmetric induction due to too large a distance between the chiral centers involved.However, addition of 2 and of the correspo
- Solladie-Cavallo, A.,Quazzotti, S.
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- PbBr2/Al-Promoted Reductive Addition of 1,1,1-trichloro-2,2,2-trifluoroethane (Flon) to Aldehydes
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Introduction of CF3CCl2 unit into aldehydes with CF3CCl3 has been perfomed successfully by the action of catalytic PbBr2 and Al foils in DMF.
- Tanaka, Hideo,Yamashita, Shiro,Katayama, Yasumi,Torii, Sigeru
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p. 2043 - 2044
(2007/10/02)
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- EFFICIENT CARBON-CARBON BOND FORMATION WITH THERMALLY STABLE 1,1-DIHALO-2,2,2-TRIFLUOROETHYLZINC REAGENT
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The zinc carbenoids CF3CX2ZnX, prepared from CF3CX3 and zinc powder in dimethylformamide, were found thermally stable to add to aldehyde carbonyls in excellent yields.
- Fujita, Makoto,Morita, Tomoe,Hiyama, Tamejiro
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p. 2135 - 2138
(2007/10/02)
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- Fluorine-Containing Organozinc Reagents. Part I. A Simple Synthesis of 2,2-Dichloro-3,3,3-trifluoropropanol
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The title compound 1, which can be regarded as synthetic equivalent of substituted 1,1,1-trifluoroacetone 2, is prepared by Zn-induced reductive addition of 1,1,1-trichloro-2,2,2-trifluoroethane (3) to formaldehyde (4).A brief survey of the scope of this C-C-bond formation leading to a variety of new CF3-containing synthetic building blocks is also given.
- Lang, Robert Werner
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p. 881 - 886
(2007/10/02)
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